METHODS: MOG-EM (n = 61) and NMOSD (n = 565) cases obtained from the MSNMOBase (2011-2018) were retrospectively reviewed.
RESULTS: Acute epileptic seizures were observed in 13 (21.3%) patients with MOG-EM and two (0.4%) patients with NMOSD (P < 0.001). In both MOG-EM and NMOSD patients, more than half of seizures were single and of focal onset; slow wave and cortical/subcortical lesions were the most common abnormalities. In MOG-EM patients, no difference was found in the proportion of single seizure with and without anti-epileptic drugs (AEDs; 64.3% vs. 45.5%, P = 0.435). Long-term AED use did not significantly reduce the occurrence of acute epileptic seizures, which was 66.7% before and after treatment. In patients with MOG-EM and NMOSD, mycophenolate mofetil significantly reduced acute epileptic seizure occurrence (P = 0.024).
CONCLUSIONS: Acute epileptic seizures were more common in MOG-EM patients than in NMOSD patients. The long-term use of AEDs might be unnecessary given the use of immunotherapy in cases of MOG-EM.
方法:对从MSNMOBase(2011-2018)获得的MOG-EM(n=61)和NMOSD(n=565)病例进行回顾性分析。
结果:在13例(21.3%)MOG-EM患者和2例(0.4%)NMOSD患者中观察到急性癫痫发作(P<0.001)。在MOG-EM和NMOSD患者中,超过一半的癫痫发作是单发和局灶性发作;慢波和皮质/皮质下病变是最常见的异常.在MOG-EM患者中,有和没有抗癫痫药物的单次发作比例没有差异(AEDs;64.3%vs.45.5%,P=0.435)。长期使用AED并没有显着减少急性癫痫发作的发生,治疗前后为66.7%。在MOG-EM和NMOSD患者中,霉酚酸酯可显著减少急性癫痫发作的发生(P=0.024)。
结论:急性癫痫发作在MOG-EM患者中比在NMOSD患者中更常见。考虑到在MOG-EM的情况下使用免疫疗法,长期使用AED可能是不必要的。