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Abstract：
Bone tissue is remodeled through the catabolic function of the osteoclasts and the anabolic function of the osteoblasts. The process of bone homeostasis and metabolism has been identified to be co-ordinated with several local and systemic factors, of which mechanical stimulation acts as an important regulator. Very recent studies have shown a mutual effect between bone and other organs, which means bone influences the activity of other organs and is also influenced by other organs and systems of the body, especially the nervous system. With the discovery of neuropeptide (calcitonin gene-related peptide, vasoactive intestinal peptide, substance P, and neuropeptide Y) and neurotransmitter in bone and the adrenergic receptor observed in osteoclasts and osteoblasts, the function of peripheral nervous system including sympathetic and sensor nerves in bone resorption and its reaction to on osteoclasts and osteoblasts under mechanical stimulus cannot be ignored. Taken together, bone tissue is not only the mechanical transmitter, but as well the receptor of neural system under mechanical loading. This review aims to summarize the relationship among bone, nervous system, and mechanotransduction.
摘要：
骨组织通过破骨细胞的分解代谢功能和成骨细胞的合成代谢功能被重塑。骨稳态和代谢的过程已被确定为与几个局部和全身因素协调。其中机械刺激作为一个重要的调节器。最近的研究表明，骨骼和其他器官之间存在相互作用，这意味着骨骼影响其他器官的活动，也受到身体其他器官和系统的影响，尤其是神经系统.随着神经肽（降钙素基因相关肽，血管活性肠肽，P物质,和神经肽Y）和骨骼中的神经递质以及破骨细胞和成骨细胞中观察到的肾上腺素能受体，周围神经系统包括交感神经和感应神经在骨吸收中的作用及其在机械刺激下对破骨细胞和成骨细胞的反应是不可忽视的。一起来看,骨组织不仅是机械发射器，还有神经系统在机械负荷下的受体。这篇综述旨在总结骨与骨之间的关系，神经系统,和机械转换。
