PDF(Sci-hub)
Abstract：
Matrix metalloproteinase-9 (MMP9) has been reported to play a key role in the pathogenesis of aortic aneurysm. However, few studies have assessed serum MMP9 levels in both abdominal aortic aneurysm (AAA) and thoracic aortic aneurysm (TAA). In this study, we investigated the serum levels of MMP9 in aortic aneurysm to evaluate its predictive and diagnostic efficacy for AAA and TAA, and explored the association of MMP9 with circulating laboratory markers.
A total of 296 subjects were enrolled, including 105 AAA patients, 79 TAA patients and 112 healthy controls. The levels of serum MMP9 were detected by enzyme-linked immunosorbent assay (ELISA).
Compared to control group, both AAA and TAA patients had higher serum MMP9 levels in the overall comparison and subgroup analysis based on subjects aged<65 years, either male or female, hypertension, non-diabetes and non-hyperlipidemia (all P<0.05). Moreover, MMP9 levels were significantly higher in TAA group than those in AAA group in the total comparison, and this discrepancy was also found in the non-diabetes, non-hyperlipidemia and aortic diameter ≥ 5.5 cm subgroup analysis. Serum MMP9 levels were influenced by age and hypertension. There was a positive association of serum MMP9 with CRP (r = 0.33, P < 0.001) and Hcy (r = 0.199, P = 0.033). Multiple logistic analyses showed that serum MMP9 was an independent risk factor for AAA and TAA. Based on receiver operating characteristic (ROC) analysis, the area under the curve (AUC) of MMP9 for predicting TAA was 0.83 with 70% sensitivity and 91% specificity, while the AUC of MMP9 to detect AAA was 0.69 and the sensitivity and specificity were 50% and 88%.
Serum MMP9 was closely related to the existence of aortic aneurysms and could be a valuable marker for the discrimination of aortic aneurysm, especially for TAA.
A total of 296 subjects were enrolled, including 105 AAA patients, 79 TAA patients and 112 healthy controls. The levels of serum MMP9 were detected by enzyme-linked immunosorbent assay (ELISA).
Compared to control group, both AAA and TAA patients had higher serum MMP9 levels in the overall comparison and subgroup analysis based on subjects aged<65 years, either male or female, hypertension, non-diabetes and non-hyperlipidemia (all P<0.05). Moreover, MMP9 levels were significantly higher in TAA group than those in AAA group in the total comparison, and this discrepancy was also found in the non-diabetes, non-hyperlipidemia and aortic diameter ≥ 5.5 cm subgroup analysis. Serum MMP9 levels were influenced by age and hypertension. There was a positive association of serum MMP9 with CRP (r = 0.33, P < 0.001) and Hcy (r = 0.199, P = 0.033). Multiple logistic analyses showed that serum MMP9 was an independent risk factor for AAA and TAA. Based on receiver operating characteristic (ROC) analysis, the area under the curve (AUC) of MMP9 for predicting TAA was 0.83 with 70% sensitivity and 91% specificity, while the AUC of MMP9 to detect AAA was 0.69 and the sensitivity and specificity were 50% and 88%.
Serum MMP9 was closely related to the existence of aortic aneurysms and could be a valuable marker for the discrimination of aortic aneurysm, especially for TAA.
摘要：
基质金属蛋白酶-9(MMP9)在主动脉瘤的发病机制中起关键作用。然而,很少有研究评估腹主动脉瘤(AAA)和胸主动脉瘤(TAA)的血清MMP9水平.在这项研究中,我们调查了主动脉瘤中MMP9的血清水平，以评估其对AAA和TAA的预测和诊断功效，并探讨了MMP9与循环实验室标志物的关联。
共纳入296名受试者，包括105例AAA患者，79名TAA患者和112名健康对照。采用酶联免疫吸附试验(ELISA)检测血清MMP9水平。
与对照组相比，在基于年龄<65岁受试者的总体比较和亚组分析中，AAA和TAA患者的血清MMP9水平均较高，无论是男性还是女性,高血压,非糖尿病和非高脂血症（均P<0.05）。此外，TAA组MMP9水平明显高于AAA组,这种差异也在非糖尿病患者中发现，非高脂血症和主动脉直径≥5.5cm亚组分析。血清MMP9水平受年龄和高血压的影响。血清MMP9水平与CRP(r=0.33,P<0.001)、Hcy(r=0.199,P=0.033)呈正相关。多因素Logistic分析显示血清MMP9是AAA和TAA的独立危险因素。基于接收机工作特性(ROC)分析,MMP9预测TAA的曲线下面积（AUC）为0.83，敏感性为70％，特异性为91％，而MMP9检测AAA的AUC为0.69，敏感性和特异性分别为50％和88％。
血清MMP9与主动脉瘤的存在密切相关，可作为鉴别主动脉瘤的一个有价值的指标。尤其是TAA。
共纳入296名受试者，包括105例AAA患者，79名TAA患者和112名健康对照。采用酶联免疫吸附试验(ELISA)检测血清MMP9水平。
与对照组相比，在基于年龄<65岁受试者的总体比较和亚组分析中，AAA和TAA患者的血清MMP9水平均较高，无论是男性还是女性,高血压,非糖尿病和非高脂血症（均P<0.05）。此外，TAA组MMP9水平明显高于AAA组,这种差异也在非糖尿病患者中发现，非高脂血症和主动脉直径≥5.5cm亚组分析。血清MMP9水平受年龄和高血压的影响。血清MMP9水平与CRP(r=0.33,P<0.001)、Hcy(r=0.199,P=0.033)呈正相关。多因素Logistic分析显示血清MMP9是AAA和TAA的独立危险因素。基于接收机工作特性(ROC)分析,MMP9预测TAA的曲线下面积（AUC）为0.83，敏感性为70％，特异性为91％，而MMP9检测AAA的AUC为0.69，敏感性和特异性分别为50％和88％。
血清MMP9与主动脉瘤的存在密切相关，可作为鉴别主动脉瘤的一个有价值的指标。尤其是TAA。
