PDF(Sci-hub)
Abstract：
Lipid rafts formed by glycosphingolipids (GSLs) on cellular membranes play important roles in innate and adaptive immunity. Lactosylceramide (LacCer) forms lipid rafts on plasma and granular membranes of human neutrophils. These LacCer-enriched lipid rafts bind directly to pathogenic components, such as pathogenic fungi-derived β-glucan and Mycobacteria-derived lipoarabinomannan via carbohydrate-carbohydrate interactions, and mediate innate immune responses to these pathogens. In contrast, a-series and o-series gangliosides form distinct rafts on CD4+ and CD8+ T cell subsets, respectively, contributing to the respective functions of these cells and stimulating adaptive immune responses through T cell receptors. These findings suggest that gangliosides play indispensable roles in T cell selection and activation. This Review introduces the involvement of GSL-enriched lipid rafts in innate and adaptive immunity.
摘要：
由鞘糖脂（GSL）在细胞膜上形成的脂筏在先天和适应性免疫中起重要作用。乳糖基神经酰胺(LacCer)在人嗜中性粒细胞的血浆和颗粒膜上形成脂筏。这些富含LacCer的脂筏直接与致病成分结合，例如通过碳水化合物-碳水化合物相互作用的病原真菌衍生的β-葡聚糖和分枝杆菌衍生的脂阿拉伯甘露聚糖，并介导对这些病原体的先天免疫反应。相比之下,a系列和o系列神经节苷脂在CD4+和CD8+T细胞亚群上形成不同的移植物，分别,有助于这些细胞各自的功能，并通过T细胞受体刺激适应性免疫反应。这些发现表明神经节苷脂在T细胞选择和激活中起着不可或缺的作用。这篇综述介绍了富含GSL的脂筏在先天和适应性免疫中的参与。
