关键词: Breast cancer Dual targeting RNA interference Synergistic immunotherapy Tumor microenvironment pH-responsiveness
Mesh : Animals Breast Neoplasms / genetics pathology therapy Cell Line, Tumor Delayed-Action Preparations / chemistry Drug Delivery Systems Female Human Umbilical Vein Endothelial Cells Humans Hydrogen-Ion Concentration Immunotherapy / methods Macrophages / metabolism pathology Mannose / analogs & derivatives Mice Mice, Inbred BALB C Nanoparticles / chemistry Placenta Growth Factor / genetics Polyethylene Glycols / chemistry RAW 264.7 Cells RNA, Small Interfering / administration & dosage genetics pharmacokinetics therapeutic use RNAi Therapeutics / methods Tumor Microenvironment Vascular Endothelial Growth Factor A / genetics
来 源: DOI:10.1016/j.biomaterials.2018.09.017