This trial ( NCT03493945 ) was registered in National Clinical Trials on April 11th 2018.
该试验(NCT03493945)于2018年4月11日在国家临床试验中注册。
快速疗效寻求试验 ( QuEST1 ) : 一项新型联合免疫治疗研究 , 旨在快速临床信号评估转移性去势抵抗性前列腺癌。
关键词: ALT-803 Brachyury Combination immunotherapy IDO1 IL-15 M7824 Metastatic castration-resistant prostate cancer PD-L1 TGF-β Tumor vaccine
Mesh : Antibodies, Bispecific / therapeutic use Antineoplastic Agents / therapeutic use Antineoplastic Combined Chemotherapy Protocols / therapeutic use B7-H1 Antigen / antagonists & inhibitors Cancer Vaccines / therapeutic use Fetal Proteins / therapeutic use Humans Immunotherapy Indoleamine-Pyrrole 2,3,-Dioxygenase / antagonists & inhibitors Interleukin-15 / antagonists & inhibitors Male Oximes / therapeutic use Prostatic Neoplasms, Castration-Resistant / drug therapy Proteins / therapeutic use Recombinant Fusion Proteins Sulfonamides / therapeutic use T-Box Domain Proteins / therapeutic use Tissue Extracts / therapeutic use Transforming Growth Factor beta / antagonists & inhibitors Treatment Outcome Vaccines, DNA Viral Vaccines / therapeutic use
来 源:
DOI:10.1186/s40425-018-0409-8
PDF(Pubmed)