PDF(Pubmed)
Abstract：
We examined acute phase protein (APP) concentrations in viral infections of dairy ruminants and assessed the potential role of characteristic patterns of APP changes in auxiliary diagnosing viral diseases. All viruses reviewed are common causes of farm animal diseases. APPs are among the first agents of immunity, and their concentrations could be diagnostically relevant. In the most common ruminant viral diseases, elevated serum amyloid A (SAA) and haptoglobin (Hp) levels in blood serum have been observed. However, since these proteins are the main APPs in many viral infections, it is impossible to use their levels for diagnosing particular infections. Decreased Cp and albumin expression could help differentiate the bluetongue virus infection from other diseases. Lastly, analysis of SAA levels in blood serum and milk could be helpful in diagnosing small ruminant lentivirus infection. While promising, APP levels can only be considered as an auxiliary tool in diagnosing viral diseases in ruminants.
摘要：
我们检查了反刍动物病毒感染中的急性期蛋白（APP）浓度，并评估了APP变化的特征模式在辅助诊断病毒性疾病中的潜在作用。审查的所有病毒都是农场动物疾病的常见原因。APP是免疫的第一批代理人，它们的浓度可能与诊断相关。在最常见的反刍动物病毒性疾病中，已观察到血清淀粉样蛋白A（SAA）和触珠蛋白（Hp）水平升高。然而,由于这些蛋白质是许多病毒感染的主要APP，使用它们的水平来诊断特定的感染是不可能的。Cp和白蛋白表达降低有助于区分蓝舌病毒感染与其他疾病。最后,分析血清和牛奶中的SAA水平可能有助于诊断小反刍动物慢病毒感染。虽然有希望，APP水平只能被认为是诊断反刍动物病毒性疾病的辅助工具。
