PDF(Pubmed)
Abstract：
Traumatic brain injury (TBI) is the main reason of lifelong disability and casualty worldwide. In the United State alone, 1.7 million traumatic events occur yearly, out of which 50,000 results in deaths. Injury to the brain could alter various biological signaling pathways such as excitotoxicity, ionic imbalance, oxidative stress, inflammation, and apoptosis which can result in various neurological disorders such as Psychosis, Depression, Alzheimer disease, Parkinson disease, etc. In literature, various reports have indicated the alteration of these pathways after traumatic brain injury but the exact mechanism is still unclear. Thus, in the first part of this article, we have tried to summarize TBI as a modulator of various neuronal signaling pathways. Currently, very few drugs are available in the market for the treatment of TBI and these drugs only provide the supportive care. Thus, in the second part of the article, based on TBI altered signaling pathways, we have tried to find out potential targets and promising therapeutic approaches in the treatment of TBI.
摘要：
创伤性脑损伤（TBI）是全球终身残疾和伤亡的主要原因。仅在美国，每年发生170万起创伤事件，其中5万人导致死亡。脑损伤可以改变各种生物信号通路，如兴奋性毒性，离子不平衡，氧化应激，炎症,和细胞凋亡可导致各种神经系统疾病，如精神病，抑郁症,阿尔茨海默病,帕金森病,等。在文学中,各种报道表明创伤性脑损伤后这些途径的改变，但确切的机制仍不清楚。因此，在本文的第一部分，我们试图将TBI概括为各种神经元信号通路的调节因子.目前,市场上很少有药物可用于治疗TBI,并且这些药物仅提供支持性护理。因此，在文章的第二部分，基于TBI改变的信号通路，我们试图找出治疗TBI的潜在靶点和有希望的治疗方法.
