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Abstract：
The emergence of bacterial resistance to available antimicrobials has prompted the search for novel antibacterial compounds to overcome this public health problem. Metal-based complexes have been much less explored than organic compounds as antimicrobials, leading to investigations of the antimicrobial properties of selected complexes in which silver may occupy the frontline due to its use as medicine since ancient times. Like silver, camphor has also long been used for medicinal purposes. However, in both cases, limited information exists concerning the mechanisms of their antimicrobial action. This work reviews the present knowledge of the antimicrobial properties of camphor-derived silver complexes, focusing on recent research on the synthesis and antimicrobial properties of complexes based on silver and camphor imines. Selected examples of the structure and antimicrobial activity relationships of ligands studied so far are presented, showing the potential of silver camphorimine complexes as novel antimicrobials.
摘要：
细菌对现有抗菌剂的耐药性的出现促使人们寻找新型抗菌化合物来克服这一公共卫生问题。与有机化合物相比，金属基络合物作为抗菌剂的研究要少得多，导致对选定络合物的抗菌性能的研究，其中银可能由于自古以来就用作药物而占据前线。像银一样，樟脑也长期用于药用。然而,在这两种情况下，关于其抗微生物作用机制的信息有限。这项工作回顾了樟脑衍生的银络合物的抗菌性能的现有知识，重点介绍了基于银和樟脑亚胺的配合物的合成和抗菌性能的最新研究。介绍了迄今为止研究的配体的结构和抗微生物活性关系的选定实例，显示了樟脑亚胺银络合物作为新型抗菌剂的潜力。
