关键词： Australia Canada Denmark FC428 clone Japan N. lactamica N. meningitides Neisseria gonorrhoeae PBP2 antimicrobial resistance ceftriaxone oligonucleotide penA penicillin-binding protein 2

Mesh ： Alleles Anti-Bacterial Agents / pharmacology Australia / epidemiology Base Sequence Carrier Proteins / genetics Ceftriaxone / pharmacology Clone Cells DNA Primers / chemistry metabolism Gene Expression Gonorrhea / diagnosis drug therapy epidemiology microbiology Humans Mosaicism Neisseria gonorrhoeae / classification drug effects genetics isolation & purification Real-Time Polymerase Chain Reaction / methods Sequence Alignment Serine-Type D-Ala-D-Ala Carboxypeptidase beta-Lactam Resistance / genetics

来  源：   DOI：10.3201/eid2408.180295   PDF(Pubmed)

Abstract：
The ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone was first observed in Japan in 2015, and in 2017, it was documented in Denmark, Canada, and Australia. Here, we describe a PCR for direct detection of the penA gene associated with this strain that can be used to enhance surveillance activities.
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