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Abstract：
Traits with a common genetic basis frequently display correlated phenotypic responses to selection or environmental conditions. In Drosophila melanogaster, pigmentation of the abdomen and a trident-shaped region on the thorax are genetically correlated. Here, we used a pooled replicated genomewide association approach (Pool-GWAS) to identify the genetic basis of variation in thoracic trident pigmentation in two Drosophila melanogaster populations. We confirmed the previously reported large effect of ebony and the association of the cosmopolitan inversion In(3R)Payne. For the first time, we identified tan as another major locus contributing to variation in trident pigmentation. Intriguingly, the regulatory variants of tan that were most strongly associated with female abdominal pigmentation also showed a strong association with trident pigmentation. We validated this common genetic basis in transgenic assays and found qualitatively similar effects on trident and abdominal pigmentation. Further work is required to determine whether this genetic correlation is favoured by natural selection or reflects a neutral by-product of a shared regulatory architecture.
摘要：
具有共同遗传基础的性状经常显示对选择或环境条件的相关表型反应。在黑腹果蝇中，腹部的色素沉着和胸部的三叉戟状区域具有遗传相关性。这里,我们使用了一种混合复制的全基因组关联方法(Pool-GWAS)来确定两个黑腹果蝇种群中胸三叉戟色素沉着变异的遗传基础.我们证实了先前报道的乌木的巨大影响以及（3R）Payne中世界性倒置的关联。第一次,我们确定tan是导致三叉戟色素沉着变化的另一个主要位点。有趣的是，与女性腹部色素沉着最密切相关的调节型tan也与三叉戟色素沉着密切相关.我们在转基因试验中验证了这种共同的遗传基础，并发现了对三叉戟和腹部色素沉着的定性相似影响。需要进一步的工作来确定这种遗传相关性是否受到自然选择的青睐或反映了共享监管架构的中性副产品。
