Abstract：
OBJECTIVE: We examined the association between vitamin K status and physical functioning over 13 years in the Longitudinal Aging Study Amsterdam.
METHODS: Longitudinal cohort study of 633 community-dwelling adults from the Longitudinal Aging Study Amsterdam (LASA) aged 55-65 years (54% women).
METHODS: At baseline (2002-2003), plasma desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) was measured with a sandwich ELISA as a marker of vitamin K status. The outcome measures handgrip strength, calf circumference, self-reported functional limitations and functional performance were obtained at baseline and four follow-up examinations. We used generalized estimating equations to determine the relationship between dp-ucMGP tertiles and the various outcome measurements after adjusting for potential confounders. The lowest dp-ucMGP tertile reflects a high vitamin K status and was the reference.
RESULTS: Mean dp-ucMGP was 376 ± 233 pmol/L and mean follow-up was 11.1 years. Participants showed a decline in the outcome measures over time. Compared with the lowest tertile, the highest dp-ucMGP tertile had: lower handgrip strength, 1.1 kg (95% confidence interval (-2.1, -0.1; P-trend <0.001); smaller calf circumference, -0.5 cm (-0.9 -0.1; P-trend = 0.018); and, only among women, a 0.7-point poorer functional performance score (-1.1, -0.3; P-interaction = 0.002). Dp-ucMGP was not related to self-reported functional limitations. No interaction effects between time and dp-ucMGP were observed.
CONCLUSIONS: Low vitamin K status was associated with lower handgrip strength, smaller calf circumference, and, in women only, with poorer functional performance score. A low vitamin K status was however not related to the 13-year decline in these measures.
METHODS: Longitudinal cohort study of 633 community-dwelling adults from the Longitudinal Aging Study Amsterdam (LASA) aged 55-65 years (54% women).
METHODS: At baseline (2002-2003), plasma desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) was measured with a sandwich ELISA as a marker of vitamin K status. The outcome measures handgrip strength, calf circumference, self-reported functional limitations and functional performance were obtained at baseline and four follow-up examinations. We used generalized estimating equations to determine the relationship between dp-ucMGP tertiles and the various outcome measurements after adjusting for potential confounders. The lowest dp-ucMGP tertile reflects a high vitamin K status and was the reference.
RESULTS: Mean dp-ucMGP was 376 ± 233 pmol/L and mean follow-up was 11.1 years. Participants showed a decline in the outcome measures over time. Compared with the lowest tertile, the highest dp-ucMGP tertile had: lower handgrip strength, 1.1 kg (95% confidence interval (-2.1, -0.1; P-trend <0.001); smaller calf circumference, -0.5 cm (-0.9 -0.1; P-trend = 0.018); and, only among women, a 0.7-point poorer functional performance score (-1.1, -0.3; P-interaction = 0.002). Dp-ucMGP was not related to self-reported functional limitations. No interaction effects between time and dp-ucMGP were observed.
CONCLUSIONS: Low vitamin K status was associated with lower handgrip strength, smaller calf circumference, and, in women only, with poorer functional performance score. A low vitamin K status was however not related to the 13-year decline in these measures.
摘要：
目的：我们在阿姆斯特丹的纵向衰老研究中研究了13年来维生素K状态与身体机能之间的关系。
方法：来自阿姆斯特丹纵向衰老研究（LASA）的633名社区居住成年人的纵向队列研究，年龄为55-65岁（54％为女性）。
方法：在基线（2002-2003），用夹心ELISA测量血浆去磷酸化未羧化基质Gla蛋白（dp-ucMGP）作为维生素K状态的标志物。结果测量手握力量，小腿周长,在基线和4次随访检查中获得了自我报告的功能限制和功能表现.我们使用广义估计方程来确定dp-ucMGP三元率与调整潜在混杂因素后的各种结果测量值之间的关系。最低的dp-ucMGP三元组反映了高维生素K状态，并且是参考。
结果：平均dp-ucMGP为376±233pmol/L，平均随访11.1年。参与者显示，随着时间的推移，结果指标有所下降。与最低三分位数相比，最高的dp-ucMGP三元组有:较低的握力，1.1kg（95％置信区间（-2.1，-0.1；P趋势<0.001）；小腿围较小，-0.5厘米(-0.9-0.1；P趋势=0.018)；和，只有在女性中，功能表现评分差0.7分（-1.1，-0.3；P-交互作用=0.002）。Dp-ucMGP与自我报告的功能限制无关。没有观察到时间和dp-ucMGP之间的相互作用效应。
结论：低维生素K状态与较低的握力有关，较小的小腿周长，and,只有女性，功能性能得分较差。然而，低维生素K状态与这些措施的13年下降无关。
方法：来自阿姆斯特丹纵向衰老研究（LASA）的633名社区居住成年人的纵向队列研究，年龄为55-65岁（54％为女性）。
方法：在基线（2002-2003），用夹心ELISA测量血浆去磷酸化未羧化基质Gla蛋白（dp-ucMGP）作为维生素K状态的标志物。结果测量手握力量，小腿周长,在基线和4次随访检查中获得了自我报告的功能限制和功能表现.我们使用广义估计方程来确定dp-ucMGP三元率与调整潜在混杂因素后的各种结果测量值之间的关系。最低的dp-ucMGP三元组反映了高维生素K状态，并且是参考。
结果：平均dp-ucMGP为376±233pmol/L，平均随访11.1年。参与者显示，随着时间的推移，结果指标有所下降。与最低三分位数相比，最高的dp-ucMGP三元组有:较低的握力，1.1kg（95％置信区间（-2.1，-0.1；P趋势<0.001）；小腿围较小，-0.5厘米(-0.9-0.1；P趋势=0.018)；和，只有在女性中，功能表现评分差0.7分（-1.1，-0.3；P-交互作用=0.002）。Dp-ucMGP与自我报告的功能限制无关。没有观察到时间和dp-ucMGP之间的相互作用效应。
结论：低维生素K状态与较低的握力有关，较小的小腿周长，and,只有女性，功能性能得分较差。然而，低维生素K状态与这些措施的13年下降无关。
