关键词： Bispecific antibodies CAR, chimeric antigen receptor CAR-T-cells CDN, cyclic dinucleotides CTL, cytotoxic T lymphocyte CTLA-4, cytotoxic T-lymphocyte-associated protein 4 GM-CSF, granulocyte-monocyte colony stimulating factor IR, irradiation Immunocytokines Immunotherapy PD-1, Programmed cell death protein 1 receptor PD-L1, PD-1 ligand Radiotherapy TCR, T cell receptor Treg, regulatory T cells Vaccination bsAb, bispecific antibody scFv, single chain variable fragment

来  源：   DOI：10.1016/j.ctro.2016.12.006   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
The revival of cancer immunotherapy has taken place with the clinical success of immune checkpoint inhibition. However, the spectrum of immunotherapeutic approaches is much broader encompassing T cell engaging strategies, tumour-specific vaccination, antibodies or immunocytokines. This review focuses on the immunological effects of irradiation and the evidence available on combination strategies with immunotherapy. The available data suggest great potential of combined treatments, yet also poses questions about dose, fractionation, timing and most promising multimodal strategies.
摘要：
随着免疫检查点抑制的临床成功，癌症免疫疗法的复兴已经发生。然而,免疫治疗方法的范围更广，包括T细胞参与策略，肿瘤特异性疫苗接种，抗体或免疫细胞因子。这篇综述的重点是辐射的免疫学作用以及与免疫治疗联合策略的可用证据。现有数据表明联合治疗的巨大潜力，但也提出了关于剂量的问题，分馏,时机和最有前途的多式联运策略。
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