关键词: 16S rRNA gene sequencing Bacteremia MALDI-TOF MS Moraxella osloensis

Mesh : Anti-Bacterial Agents / therapeutic use Bacteremia / drug therapy microbiology Child Humans Male Moraxella / isolation & purification Moraxellaceae Infections / drug therapy microbiology Polymerase Chain Reaction Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Treatment Outcome

来  源:   DOI:10.1016/j.bjid.2017.10.008

Abstract:
Herein we report the case of a 10-year-old boy with an autosomal mosaic mutation who developed bacteremia. The causative agent was identified as Moraxella osloensis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 16S rRNA gene sequencing. In the pediatric population, there have been 13 case reports of infection attributed to M. osloensis and this is the fifth reported case of pediatric bacteremia due to M. osloensis. After Moraxella species infection was confirmed, the patient recovered with appropriate antimicrobial therapy. It is important to consider that M. osloensis can cause serious infections, such as bacteremia, in otherwise healthy children.
摘要:
在此,我们报告了一个10岁的常染色体镶嵌突变男孩发生菌血症的病例。通过基质辅助激光解吸/电离飞行时间质谱和16SrRNA基因测序将病原体鉴定为osloensis莫拉氏菌。在儿科人群中,有13例报告的感染归因于osloensisM.,这是第五例报告的儿童菌血症由于osloensis。在确认莫拉氏菌属感染后,患者通过适当的抗菌治疗康复。重要的是要考虑到osloensis可以引起严重的感染,比如菌血症,在其他健康的孩子身上。
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