Severe post-artesunate delayed onset anaemia responding to corticotherapy: a case report.

对皮质治疗有反应的重度青蒿琥酯后迟发性贫血 ： 一例。

• 影响指数: 39.194
• 发表时间: 01 2018 1
• 来源期刊: J Travel Med
• DOI: 10.1093/jtm/tax091
• PMID: 29394387
• 文章类型: Case Reports
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Lebrun D,Floch T,Brunet A,Julien G,Romaru J,N'Guyen Y,Cousson J,Giltat A,Toubas D,Bani-Sadr F

关键词: Post-artesunate delayed onset anaemia; autoimmune haemolysis; pitting; post-artemisin delayed onset haemolysis; post-artesunate delayed onset haemolysis; severe malaria

Mesh: Administration, Intravenous; Adrenal Cortex Hormones / therapeutic use; Adult; Anemia, Hemolytic / drug therapy parasitology; Artemisinins / therapeutic use; Artesunate / therapeutic use; Coombs Test; Hemolysis / drug effects; Humans; Malaria, Falciparum / complications drug therapy; Male; Parasitemia / complications drug therapy; Travel

Abstract

Delayed onset haemolysis occurring post-artesunate and post-artemisinin combination therapy is secondary to delayed clearance of infected erythrocytes spared by pitting during treatment. We report a case of severe post-treatment delayed haemolytic anaemia with a positive direct antiglobulin test and a positive response to corticosteroid therapy, suggesting an associated immune mechanism.

摘要

青蒿琥酯和青蒿素联合治疗后发生的延迟性溶血是继发于治疗期间因点蚀而幸免的感染红细胞的延迟清除。我们报告了一例严重的治疗后迟发性溶血性贫血，其直接抗球蛋白试验阳性，对皮质类固醇治疗反应阳性。提示相关的免疫机制。