转录因子 NANOG 和 OTX2 之间的拮抗作用指定了神经模式转换过程中的头端或尾细胞命运。
关键词: NANOG OTX2 Wnt signaling cell biology cell differentiation human neural stem cell (NSC) neurodifferentiation
Mesh : Body Patterning Cell Differentiation Cell Lineage Cells, Cultured Gene Expression Regulation, Developmental Humans Inferior Colliculi / cytology metabolism Midbrain Raphe Nuclei / cytology metabolism Nanog Homeobox Protein / metabolism Neural Stem Cells / cytology metabolism Neurogenesis Neurons / cytology metabolism Otx Transcription Factors / metabolism Pluripotent Stem Cells / cytology metabolism Prosencephalon / cytology metabolism Rhombencephalon / cytology metabolism
来 源:
DOI:10.1074/jbc.M117.815449
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