CRL4 拮抗 SCFFbxo7 介导的小脑和 BK 通道的周转以调节学习和记忆。
Mesh : Adaptor Proteins, Signal Transducing Animals Cells, Cultured Female HEK293 Cells Humans Intellectual Disability / genetics metabolism Large-Conductance Calcium-Activated Potassium Channels / metabolism Learning / physiology Male Memory / physiology Mice Mice, Inbred C57BL Mice, Transgenic Nerve Tissue Proteins / metabolism Proteolysis SKP Cullin F-Box Protein Ligases / antagonists & inhibitors metabolism Ubiquitin-Protein Ligase Complexes / genetics metabolism Ubiquitin-Protein Ligases / genetics physiology Ubiquitination
来 源:
DOI:10.1371/journal.pgen.1007165
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