PDF(Pubmed)
Abstract：
Little is known about the causes of childhood cancer, partly as not many children develop cancer, although childhood cancer is a leading cause of death by disease in the young. The young age of the children suggests that risk factors for childhood cancer may be present during pregnancy. Previous studies have shown that exposure to trans-fat, a type of unsaturated fat common in industrially produced foods (iTFA), has adverse health effects in adults, including the risk of developing cancer. Haematopoietic neoplasms are the most common cancer types among European children under the age of 15 years. This study will bring new knowledge as to whether trans-fat and other fatty acids may also increase the risk of developing haematopoietic neoplasms during childhood.
We will investigate if the Danish iTFA legislation ban, which radically reduced the use of iTFA in foodstuffs, influenced the risk of childhood haematopoietic neoplasms in children born either before or after the change in legislation, adjusting for relevant secular trends. Further, in a case-control study, we will examine if levels of fatty acids in dried blood spots from newborns can predict the risk of developing childhood haematopoietic neoplasms. Permission from the Danish Data Protection Agency and the Ethical Committee has been granted.
The results from this study will provide important information about fatty acids in the mother\'s diet as a contributor to development of haematopoietic neoplasms during childhood, which may result in relevant preventive action.
Not relevant.
We will investigate if the Danish iTFA legislation ban, which radically reduced the use of iTFA in foodstuffs, influenced the risk of childhood haematopoietic neoplasms in children born either before or after the change in legislation, adjusting for relevant secular trends. Further, in a case-control study, we will examine if levels of fatty acids in dried blood spots from newborns can predict the risk of developing childhood haematopoietic neoplasms. Permission from the Danish Data Protection Agency and the Ethical Committee has been granted.
The results from this study will provide important information about fatty acids in the mother\'s diet as a contributor to development of haematopoietic neoplasms during childhood, which may result in relevant preventive action.
Not relevant.
摘要：
对儿童癌症的病因知之甚少，部分原因是没有多少儿童患上癌症，虽然儿童癌症是年轻人死亡的主要原因。儿童的年龄较小，这表明在怀孕期间可能存在儿童癌症的危险因素。以前的研究表明，接触反式脂肪，工业生产食品(iTFA)中常见的一种不饱和脂肪，对成年人有不利的健康影响，包括患癌症的风险。造血肿瘤是欧洲15岁以下儿童中最常见的癌症类型。这项研究将为反式脂肪和其他脂肪酸是否也可能增加儿童期发生造血肿瘤的风险带来新的知识。
我们将调查丹麦iTFA立法是否禁止，从根本上减少了食品中iTFA的使用，影响了在立法变更之前或之后出生的儿童患儿童造血肿瘤的风险，适应相关的长期趋势。Further,在一项病例对照研究中，我们将研究新生儿干血斑中的脂肪酸水平是否可以预测儿童造血肿瘤的风险。丹麦数据保护局和道德委员会已获得许可。
这项研究的结果将提供有关母亲饮食中的脂肪酸作为儿童时期造血肿瘤发展的一个重要信息。这可能导致相关的预防措施。
不相关。
我们将调查丹麦iTFA立法是否禁止，从根本上减少了食品中iTFA的使用，影响了在立法变更之前或之后出生的儿童患儿童造血肿瘤的风险，适应相关的长期趋势。Further,在一项病例对照研究中，我们将研究新生儿干血斑中的脂肪酸水平是否可以预测儿童造血肿瘤的风险。丹麦数据保护局和道德委员会已获得许可。
这项研究的结果将提供有关母亲饮食中的脂肪酸作为儿童时期造血肿瘤发展的一个重要信息。这可能导致相关的预防措施。
不相关。
