PDF(Pubmed)
Abstract：
Results on the relationships between vitamin D receptor (VDR) gene polymorphisms and postmenopausal osteoporosis (PMOP) susceptibility and bone mineral density (BMD) are conflicting. The aim of the study is to identify more eligible studies that calculated pooled OR and WMD with 95% CI to assess their associations. Overall, there were significant correlations between VDR ApaI, VDR FokI and PMOP susceptibility. Subgroup analysis showed that VDR ApaI polymorphism significantly decreased the osteoporosis risk in Caucasian postmenopausal women. In Asian populations, VDR BsmI and VDR FokI were associated with an increased risk of PMOP. As to the associations between VDR polymorphisms and BMD, Caucasian PMOP women carrying the ApaI aa genotype were at risk of high BMD in femoral neck, and low femoral neck BMD was observed in Caucasian PMOP women with FokI Ff genotype. PMOP women with the Cdx2 GA genotype had a lower lumbar spine BMD in overall and Caucasian populations compared with PMOP women with GG genotype. Different VDR gene polymorphisms have different impacts on PMOP risk and BMD.
摘要：
关于维生素D受体（VDR）基因多态性与绝经后骨质疏松症（PMOP）易感性和骨密度（BMD）之间的关系的结果是矛盾的。该研究的目的是确定更多符合条件的研究，这些研究计算了具有95％CI的合并OR和WMD，以评估它们的关联。总的来说,VDRApaI之间存在显著相关性，VDRFokI和PMOP易感性。亚组分析表明，VDRApaI多态性显着降低了高加索绝经后妇女的骨质疏松症风险。在亚洲人口中，VDRBsmI和VDRFokI与PMOP风险增加相关。关于VDR多态性与BMD的关系,携带ApaIaa基因型的高加索PMOP女性在股骨颈有高BMD的风险，在具有FokIFf基因型的高加索PMOP女性中观察到低股骨颈BMD。与具有GG基因型的PMOP女性相比，具有Cdx2GA基因型的PMOP女性在总体和高加索人群中的腰椎BMD较低。不同的VDR基因多态性对PMOP风险和BMD有不同的影响。
