硫化氢通过降低对磷脂磷脂酰肌醇 4, 5 - 二磷酸 (PIP2) 的敏感性来抑制 Kir2 和 Kir3 通道。
关键词: GIRK channels KATP channels Kir3 Kir3 or GIRK channels gasotransmitters hydrogen sulfide inwardly rectifying K+ (Kir) channels ischemia phosphatidylinositol 4,5-bisphosphate (PIP2) phosphoinositide potassium channel stroke
Mesh : Allosteric Regulation / drug effects Amino Acid Substitution Animals CHO Cells Cricetulus Cystathionine gamma-Lyase / genetics metabolism G Protein-Coupled Inwardly-Rectifying Potassium Channels / antagonists & inhibitors chemistry genetics metabolism Hydrogen Sulfide / chemistry metabolism pharmacology Mice Models, Molecular Molecular Dynamics Simulation Mutagenesis, Site-Directed Mutation Oocytes / cytology metabolism Patch-Clamp Techniques Phosphatidylinositol 4,5-Diphosphate / chemistry metabolism Potassium Channels, Inwardly Rectifying / antagonists & inhibitors chemistry genetics metabolism Protein Conformation Recombinant Fusion Proteins / chemistry metabolism Recombinant Proteins / chemistry metabolism Sulfides / chemistry metabolism pharmacology Xenopus laevis
来 源:
DOI:10.1074/jbc.RA117.001679
PDF(Sci-hub)