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Abstract：
In today\'s world of modern medicine and novel therapies, cancer still remains to be one of the prime contributor to the death of people worldwide. The modern therapies improve condition of cancer patients and are effective in early stages of cancer but the advanced metastasized stage of cancer remains untreatable. Also most of the cancer therapies are expensive and are associated with adverse side effects. Thus, considering the current status of cancer treatment there is scope to search for efficient therapies which are cost-effective and are associated with lesser and milder side effects. Phytochemicals have been utilized for many decades to prevent and cure various ailments and current evidences indicate use of phytochemicals as an effective treatment for cancer. Hyperactivation of phosphoinositide 3-kinase (PI3K) signaling cascades is a common phenomenon in most types of cancers. Thus, natural substances targeting PI3K pathway can be of great therapeutic potential in the treatment of cancer patients. This chapter summarizes the updated research on plant-derived substances targeting PI3K pathway and the current status of their preclinical studies and clinical trials.
摘要：
在今天的现代医学和新疗法的世界，癌症仍然是全球人民死亡的主要原因之一。现代疗法改善了癌症患者的状况，并且在癌症的早期阶段有效，但癌症的晚期转移阶段仍然无法治疗。此外,大多数癌症疗法是昂贵的并且与不良副作用相关。因此，考虑到癌症治疗的现状，我们仍有寻找有效的治疗方法的余地，这些治疗方法具有成本效益，并且副作用较小和较温和。植物化学品已经使用了几十年来预防和治疗各种疾病，目前的证据表明使用植物化学品作为癌症的有效治疗方法。磷酸肌醇3激酶（PI3K）信号级联的过度激活是大多数类型癌症中的普遍现象。因此，靶向PI3K途径的天然物质在癌症患者的治疗中具有巨大的治疗潜力。本章总结了针对PI3K途径的植物衍生物质的最新研究及其临床前研究和临床试验的现状。
