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Abstract：
Post-infectious irritable bowel syndrome is a well-defined pathological entity that develops in about one-third of subjects after an acute infection (bacterial, viral) or parasitic infestation. Only recently it has been documented that an high incidence of post-infectious irritable bowel syndrome occurs after Clostridium difficile infection. However, until now it is not known why in some patients recovered from this infection the gastrointestinal disturbances persist for months or years. Based on our in vitro studies on enteric glial cells exposed to the effects of C. difficile toxin B, we hypothesize that persistence of symptoms up to the development of irritable bowel syndrome might be due to a disturbance/impairment of the correct functions of the enteroglial intestinal network.
摘要：
感染后肠易激综合征是一种明确定义的病理实体，在急性感染后约有三分之一的受试者（细菌，病毒)或寄生虫侵扰。直到最近才有记录表明，艰难梭菌感染后感染后肠易激综合征的发病率很高。然而,到目前为止，还不知道为什么一些患者从这种感染中康复，胃肠道紊乱持续数月或数年。根据我们对暴露于艰难梭菌毒素B作用的肠胶质细胞的体外研究，我们假设肠易激综合征发展之前的症状持续可能是由于肠胶质肠网络的正常功能紊乱/受损所致.
