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Abstract：
As dietary components are delivered directly to the periportal zone of the liver lobule, there is the potential for greater injury in this zone (zone 1) compared to the perivenous zone (zone 3). We investigated the associations between dietary fructose consumption and uric acid concentrations and differential zonal injury in periportal and perivenous zones.
A total of 271 children\'s histological images were scored in 5 periportal and 5 perivenous zones for steatosis, ballooning, inflammation and fibrosis severity. Dietary fructose consumption (g/d) was assessed and uric acid measured in serum. Logistic regression was undertaken to test associations between both high fructose consumption and hyperuricaemia, and histological disease in periportal and perivenous zones.
Children with a mean age of 12.5 years were included in the study. Inflammation (mean ± SD) was increased in the periportal vs perivenous zones (0.78 ± 0.43 vs 0.41 ± 0.48, P = .041). There were non-significant trends towards greater steatosis, ballooning and fibrosis in the periportal zone. In the fully adjusted models, high fructose intake was associated with disease in both zones. Example for periportal and perivenous zones, respectively, steatosis 1.56 (1.12, 2.49) and 1.21 (1.09, 2.73); inflammation 4.29 (2.31, 5.88) and 3.69 (2.14, 4.56); and fibrosis 2.72 (1.43, 3.76) and 1.96 (1.24, 2.37). Hyperuricaemia (uric acid ≥5.9 mg/dL) was associated with inflammation in the periportal zone 1.71 (1.17, 2.35); and was associated with steatosis and fibrosis in both zones; for example, for periportal and perivenous zones, respectively, steatosis 2.98 (1.65, 3.23) and 1.14 (1.05, 1.99); and fibrosis, 2.65 (1.35, 2.99) and 1.31 (1.13, 2.17).
High fructose consumption is associated with disease severity in both lobular zones and hyperuricaemia may be associated with more severe disease in the periportal zone.
A total of 271 children\'s histological images were scored in 5 periportal and 5 perivenous zones for steatosis, ballooning, inflammation and fibrosis severity. Dietary fructose consumption (g/d) was assessed and uric acid measured in serum. Logistic regression was undertaken to test associations between both high fructose consumption and hyperuricaemia, and histological disease in periportal and perivenous zones.
Children with a mean age of 12.5 years were included in the study. Inflammation (mean ± SD) was increased in the periportal vs perivenous zones (0.78 ± 0.43 vs 0.41 ± 0.48, P = .041). There were non-significant trends towards greater steatosis, ballooning and fibrosis in the periportal zone. In the fully adjusted models, high fructose intake was associated with disease in both zones. Example for periportal and perivenous zones, respectively, steatosis 1.56 (1.12, 2.49) and 1.21 (1.09, 2.73); inflammation 4.29 (2.31, 5.88) and 3.69 (2.14, 4.56); and fibrosis 2.72 (1.43, 3.76) and 1.96 (1.24, 2.37). Hyperuricaemia (uric acid ≥5.9 mg/dL) was associated with inflammation in the periportal zone 1.71 (1.17, 2.35); and was associated with steatosis and fibrosis in both zones; for example, for periportal and perivenous zones, respectively, steatosis 2.98 (1.65, 3.23) and 1.14 (1.05, 1.99); and fibrosis, 2.65 (1.35, 2.99) and 1.31 (1.13, 2.17).
High fructose consumption is associated with disease severity in both lobular zones and hyperuricaemia may be associated with more severe disease in the periportal zone.
摘要：
由于饮食成分直接输送到肝小叶的门静脉周围区，与静脉周围区域（区域3）相比，该区域（区域1）的损伤可能更大。我们调查了饮食果糖消耗与尿酸浓度以及门静脉周围和静脉周围区域差异区域损伤之间的关系。
共有271名儿童的组织学图像在5个门静脉周围区和5个静脉周围区进行脂肪变性评分，气球，炎症和纤维化严重程度。评估膳食果糖消耗(g/d)并测量血清中的尿酸。进行Logistic回归以测试高果糖消耗和高尿酸血症之间的关联。以及门静脉周围和静脉周围区域的组织学疾病。
研究对象包括平均年龄为12.5岁的儿童。门静脉周围和静脉周围区域的炎症（平均值±SD）增加（0.78±0.43vs0.41±0.48，P=.041）。脂肪变性没有明显的趋势，门静脉周围区的膨胀和纤维化。在完全调整的模型中，高果糖摄入与两个地区的疾病有关。门静脉周围和静脉周围区域的例子，分别,脂肪变性1.56（1.12，2.49）和1.21（1.09，2.73）;炎症4.29（2.31，5.88）和3.69（2.14，4.56）;和纤维化2.72（1.43，3.76）和1.96（1.24，2.37）。高尿酸血症（尿酸≥5.9mg/dL）与门静脉周区1.71（1.17，2.35）的炎症有关；并且与两个区域的脂肪变性和纤维化有关；例如，对于门静脉周围和静脉周围区域，分别,脂肪变性2.98（1.65，3.23）和1.14（1.05，1.99）；和纤维化，2.65(1.35,2.99)和1.31(1.13,2.17)。
高果糖消耗与小叶区的疾病严重程度相关，高尿酸血症可能与门静脉周围区更严重的疾病相关。
共有271名儿童的组织学图像在5个门静脉周围区和5个静脉周围区进行脂肪变性评分，气球，炎症和纤维化严重程度。评估膳食果糖消耗(g/d)并测量血清中的尿酸。进行Logistic回归以测试高果糖消耗和高尿酸血症之间的关联。以及门静脉周围和静脉周围区域的组织学疾病。
研究对象包括平均年龄为12.5岁的儿童。门静脉周围和静脉周围区域的炎症（平均值±SD）增加（0.78±0.43vs0.41±0.48，P=.041）。脂肪变性没有明显的趋势，门静脉周围区的膨胀和纤维化。在完全调整的模型中，高果糖摄入与两个地区的疾病有关。门静脉周围和静脉周围区域的例子，分别,脂肪变性1.56（1.12，2.49）和1.21（1.09，2.73）;炎症4.29（2.31，5.88）和3.69（2.14，4.56）;和纤维化2.72（1.43，3.76）和1.96（1.24，2.37）。高尿酸血症（尿酸≥5.9mg/dL）与门静脉周区1.71（1.17，2.35）的炎症有关；并且与两个区域的脂肪变性和纤维化有关；例如，对于门静脉周围和静脉周围区域，分别,脂肪变性2.98（1.65，3.23）和1.14（1.05，1.99）；和纤维化，2.65(1.35,2.99)和1.31(1.13,2.17)。
高果糖消耗与小叶区的疾病严重程度相关，高尿酸血症可能与门静脉周围区更严重的疾病相关。
