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Abstract：
UNASSIGNED: To analyze the correlation between neck circumference (NC) and non-alcoholic fatty liver disease (NAFLD) and compare the predictive value of NC for NAFLD with that of other simple anthropometric measures and other biochemical profiles.
UNASSIGNED: 2761 subjects, undergoing a medical check-up at the Changhai Hospital between October 01, 2012 and November 30, 2012, were recruited to the study. NC, other simple anthropometric measures, and biochemical profiles were analyzed.
UNASSIGNED: NC in NAFLD subjects with or without elevated ALT were 38.94 ± 2.62 cm and 37.21 ± 3.06 cm respectively, which was significantly higher than that in subjects with other metabolic disorders (NC: 35.33 ± 3.03 cm) and in normal controls (NC: 32.60 ± 2.37) (both P < 0.001). NC in women with NAFLD increased by 1 cm and fasting insulin (FINS) and homeostasis model assessment-insulin resistance (HOMA-IR) increased by 1.87 mIU/L and 1.43, respectively. Compared with other anthropometric measures, neck circumference-height ratio (NHtR) had a significant impact both on the incidence of NAFLD. After adjustment for sex, abdominal obesity and other influencing factors, the incidence of NAFLD still tended to positively correlate with NC. Optimal cut-off points of NC and NHtR for predicting NAFLD in males were 37.25 cm and 0.224, respectively, and such points in females were 32.90 cm and 0.208, respectively.
UNASSIGNED: NC was wider in NAFLD patients than in healthy subjects and other metabolic disorder sufferers. NC and NHtR could be used as simple predictive tools for NAFLD.
UNASSIGNED: 2761 subjects, undergoing a medical check-up at the Changhai Hospital between October 01, 2012 and November 30, 2012, were recruited to the study. NC, other simple anthropometric measures, and biochemical profiles were analyzed.
UNASSIGNED: NC in NAFLD subjects with or without elevated ALT were 38.94 ± 2.62 cm and 37.21 ± 3.06 cm respectively, which was significantly higher than that in subjects with other metabolic disorders (NC: 35.33 ± 3.03 cm) and in normal controls (NC: 32.60 ± 2.37) (both P < 0.001). NC in women with NAFLD increased by 1 cm and fasting insulin (FINS) and homeostasis model assessment-insulin resistance (HOMA-IR) increased by 1.87 mIU/L and 1.43, respectively. Compared with other anthropometric measures, neck circumference-height ratio (NHtR) had a significant impact both on the incidence of NAFLD. After adjustment for sex, abdominal obesity and other influencing factors, the incidence of NAFLD still tended to positively correlate with NC. Optimal cut-off points of NC and NHtR for predicting NAFLD in males were 37.25 cm and 0.224, respectively, and such points in females were 32.90 cm and 0.208, respectively.
UNASSIGNED: NC was wider in NAFLD patients than in healthy subjects and other metabolic disorder sufferers. NC and NHtR could be used as simple predictive tools for NAFLD.
摘要：
■分析颈围（NC）与非酒精性脂肪性肝病（NAFLD）之间的相关性，并比较NC对NAFLD的预测价值与其他简单的人体测量法和其他生化指标的预测价值。
■2761个科目，2012年10月01日至2012年11月30日期间在长海医院接受体检的患者被招募到本研究.NC,其他简单的人体测量，并进行了生化分析。
■有或没有ALT升高的NAFLD受试者的NC分别为38.94±2.62cm和37.21±3.06cm，显着高于其他代谢紊乱受试者（NC：35.33±3.03cm）和正常对照组（NC：32.60±2.37）（均P<0.001）。NAFLD女性的NC增加1cm，空腹胰岛素（FINS）和稳态模型评估-胰岛素抵抗（HOMA-IR）分别增加1.87mIU/L和1.43。与其他人体测量相比，颈围-身高比(NHtR)对NAFLD的发病率均有显著影响.在性别调整后，腹型肥胖等影响因素,NAFLD的发生率仍与NC呈正相关。预测男性NAFLD的NC和NHtR的最佳切点分别为37.25cm和0.224,女性的这些点分别为32.90厘米和0.208。
■NAFLD患者的NC比健康受试者和其他代谢紊乱患者的更宽。NC和NHtR可用作NAFLD的简单预测工具。
■2761个科目，2012年10月01日至2012年11月30日期间在长海医院接受体检的患者被招募到本研究.NC,其他简单的人体测量，并进行了生化分析。
■有或没有ALT升高的NAFLD受试者的NC分别为38.94±2.62cm和37.21±3.06cm，显着高于其他代谢紊乱受试者（NC：35.33±3.03cm）和正常对照组（NC：32.60±2.37）（均P<0.001）。NAFLD女性的NC增加1cm，空腹胰岛素（FINS）和稳态模型评估-胰岛素抵抗（HOMA-IR）分别增加1.87mIU/L和1.43。与其他人体测量相比，颈围-身高比(NHtR)对NAFLD的发病率均有显著影响.在性别调整后，腹型肥胖等影响因素,NAFLD的发生率仍与NC呈正相关。预测男性NAFLD的NC和NHtR的最佳切点分别为37.25cm和0.224,女性的这些点分别为32.90厘米和0.208。
■NAFLD患者的NC比健康受试者和其他代谢紊乱患者的更宽。NC和NHtR可用作NAFLD的简单预测工具。
