Abstract：
BACKGROUND: Prosthetic replacement of the ocular surface ecosystem (PROSE) treatment is an effective, nonsurgical therapeutic option for patients with ocular surface disease related to cranial nerve deficits secondary to skull base tumor resection.
METHODS: This case series describes the impact of PROSE treatment in patients with symptomatic exposure keratopathy or neurotrophic keratitis after skull base tumor surgery.
RESULTS: All patients improved symptomatically and functionally with PROSE treatment, and have had sustained improvement for as long as 3 years.
CONCLUSIONS: In postneurosurgical cases in which neurologic function may recover, PROSE treatment offers a safe, nonsurgical treatment option to support the ocular surface during the period of observation awaiting neurologic recovery.
METHODS: This case series describes the impact of PROSE treatment in patients with symptomatic exposure keratopathy or neurotrophic keratitis after skull base tumor surgery.
RESULTS: All patients improved symptomatically and functionally with PROSE treatment, and have had sustained improvement for as long as 3 years.
CONCLUSIONS: In postneurosurgical cases in which neurologic function may recover, PROSE treatment offers a safe, nonsurgical treatment option to support the ocular surface during the period of observation awaiting neurologic recovery.
摘要：
背景：人工替代眼表生态系统（PROSE）治疗是一种有效的，颅底肿瘤切除术后继发颅神经功能缺损眼表疾病患者的非手术治疗选择。
方法：本病例系列描述了PROSE治疗对颅底肿瘤手术后有症状性暴露性角膜病变或神经营养性角膜炎患者的影响。
结果：所有患者经PROSE治疗后症状和功能均得到改善，并在长达3年的时间里持续改善。
结论：在可能恢复神经功能的神经外科手术后病例中，PROSE治疗提供了一个安全的，在等待神经系统恢复的观察期间支持眼表的非手术治疗选择。
方法：本病例系列描述了PROSE治疗对颅底肿瘤手术后有症状性暴露性角膜病变或神经营养性角膜炎患者的影响。
结果：所有患者经PROSE治疗后症状和功能均得到改善，并在长达3年的时间里持续改善。
结论：在可能恢复神经功能的神经外科手术后病例中，PROSE治疗提供了一个安全的，在等待神经系统恢复的观察期间支持眼表的非手术治疗选择。
