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Abstract：
Matricellular proteins differ from other classical extracellular matrix proteins; for instance, they are transiently expressed as soluble proteins rather than being constitutively expressed in pathological conditions, such as acute viral infections. Accumulating studies have revealed that matricellular proteins, including osteopontin and tenascin-C, both of which interact with integrin heterodimers, are involved in inflammatory diseases, autoimmune disorders, and cancers. The concentrations of these matricellular proteins are elevated in the plasma of patients with certain types of cancers, indicating that they play important roles in oncogenesis. Chronic viral infections are associated with certain cancers, which are distinct from non-viral cancers. Viral oncogenes play critical roles in the development and progression of such cancers. It is vital to investigate the mechanisms of tumorigenesis and, particularly, the mechanism by which viral proteins induce tumor progression. Viral proteins have been shown to influence not only the viral-infected cancer cells, but also the stromal cells and matricellular proteins that constitute the extracellular matrix that surrounds tumor tissues. In this review, we summarize the recent progress on the involvement of matricellular proteins in oncogenic virus-induced cancers to elucidate the mechanism of oncogenesis and consider the possible role of matricellular proteins as therapeutic targets in virus-induced cancers.
摘要：
基质细胞蛋白不同于其他经典的细胞外基质蛋白;例如，它们作为可溶性蛋白质瞬时表达，而不是在病理条件下组成型表达，如急性病毒感染。越来越多的研究表明，基质细胞蛋白，包括骨桥蛋白和生腱蛋白C,两者都与整合素异源二聚体相互作用，与炎症性疾病有关，自身免疫性疾病，和癌症。这些细胞蛋白的浓度在某些类型癌症患者的血浆中升高，表明它们在肿瘤发生中起重要作用。慢性病毒感染与某些癌症有关，与非病毒癌症不同。病毒致癌基因在此类癌症的发展和进展中起关键作用。研究肿瘤发生的机制至关重要，特别是,病毒蛋白诱导肿瘤进展的机制。病毒蛋白已被证明不仅影响病毒感染的癌细胞，还有构成围绕肿瘤组织的细胞外基质的基质细胞和基质细胞蛋白。在这次审查中,我们总结了基质细胞蛋白参与致癌病毒诱导的癌症的最新进展，以阐明肿瘤发生的机制，并考虑基质细胞蛋白作为病毒诱导的癌症治疗靶点的可能作用。
