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Abstract：
BACKGROUND: Osteoarthritis (OA) is a complex disease which can be caused by both environmental and genetic factors. A functional locus rs143383 of bone morphogenetic protein-14 (BMP-14) has been pointed out to be associated with OA etiology, but conflicting conclusions have been reached. To provide a more comprehensive conclusion about this issue, we performed this meta-analysis.
METHODS: Relevant studies were searched from electronic databases including PubMed, Chinese National Knowledge Infrastructure, Embase, and Wanfang. The strength of correlations was examined with pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Subgroup analyses stratified by ethnicity and source of control were carried out. All statistical analyses were performed with STATA software (version 12.0).
RESULTS: Overall, BMP-14 rs143383 polymorphism was negatively correlated with the susceptibility to knee OA and hand OA under genetic contrasts of CC versus TT, CC + TC versus TT, CC versus TT + TC, C versus T, TC versus TT (OR = 0.71, 95% CI = 0.65-0.79; OR = 0.81, 95% CI = 0.73-0.89; OR = 0.79, 95% CI = 0.71-0.86; OR = 0.85, 95% CI = 0.81-0.90; OR = 0.84, 95% CI = 0.75-0.93), and TC versus TT, CC versus TT + TC, C versus T (OR = 0.76, 95% CI = 0.65-0.89; OR = 0.79, 95% CI = 0.68-0.92; OR = 0.90, 95% CI = 0.85-0.95), respectively; similar results were observed in subgroups after stratification analyses. Additionally, the polymorphism also reduced hip OA risk in Asian group after stratified analysis by ethnicity.
CONCLUSIONS: BMP-14 rs143383 polymorphism may be a protective factor against OA occurrence.
METHODS: Relevant studies were searched from electronic databases including PubMed, Chinese National Knowledge Infrastructure, Embase, and Wanfang. The strength of correlations was examined with pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Subgroup analyses stratified by ethnicity and source of control were carried out. All statistical analyses were performed with STATA software (version 12.0).
RESULTS: Overall, BMP-14 rs143383 polymorphism was negatively correlated with the susceptibility to knee OA and hand OA under genetic contrasts of CC versus TT, CC + TC versus TT, CC versus TT + TC, C versus T, TC versus TT (OR = 0.71, 95% CI = 0.65-0.79; OR = 0.81, 95% CI = 0.73-0.89; OR = 0.79, 95% CI = 0.71-0.86; OR = 0.85, 95% CI = 0.81-0.90; OR = 0.84, 95% CI = 0.75-0.93), and TC versus TT, CC versus TT + TC, C versus T (OR = 0.76, 95% CI = 0.65-0.89; OR = 0.79, 95% CI = 0.68-0.92; OR = 0.90, 95% CI = 0.85-0.95), respectively; similar results were observed in subgroups after stratification analyses. Additionally, the polymorphism also reduced hip OA risk in Asian group after stratified analysis by ethnicity.
CONCLUSIONS: BMP-14 rs143383 polymorphism may be a protective factor against OA occurrence.
摘要：
背景：骨关节炎（OA）是一种复杂的疾病，可由环境和遗传因素引起。骨形态发生蛋白-14（BMP-14）的功能位点rs143383已被指出与OA病因有关，但是得出了相互矛盾的结论。为了对这个问题提供更全面的结论，我们进行了荟萃分析.
方法：从包括PubMed，中国国家知识基础设施，Embase,还有万方。用合并比值比（OR）和95％置信区间（95％CIs）检查相关性的强度。进行了按种族和控制来源分层的亚组分析。所有统计分析均使用STATA软件（12.0版）进行。
结果：总体而言，BMP-14rs143383多态性与CC和TT的遗传对比下膝关节OA和手OA的易感性呈负相关，CC+TC与TT,CC与TT+TC,C与T,TC与TT（OR=0.71，95％CI=0.65-0.79；OR=0.81，95％CI=0.73-0.89；OR=0.79，95％CI=0.71-0.86；OR=0.85，95％CI=0.81-0.90；OR=0.84，95％CI=0.75-0.93），TC和TT，CC与TT+TC,C与T（OR=0.76，95％CI=0.65-0.89；OR=0.79，95％CI=0.68-0.92；OR=0.90，95％CI=0.85-0.95），分别;在分层分析后的亚组中观察到相似的结果.此外,在按种族进行分层分析后,该多态性也降低了亚洲人群的髋关节OA风险.
结论：BMP-14rs143383多态性可能是OA发生的保护因素。
方法：从包括PubMed，中国国家知识基础设施，Embase,还有万方。用合并比值比（OR）和95％置信区间（95％CIs）检查相关性的强度。进行了按种族和控制来源分层的亚组分析。所有统计分析均使用STATA软件（12.0版）进行。
结果：总体而言，BMP-14rs143383多态性与CC和TT的遗传对比下膝关节OA和手OA的易感性呈负相关，CC+TC与TT,CC与TT+TC,C与T,TC与TT（OR=0.71，95％CI=0.65-0.79；OR=0.81，95％CI=0.73-0.89；OR=0.79，95％CI=0.71-0.86；OR=0.85，95％CI=0.81-0.90；OR=0.84，95％CI=0.75-0.93），TC和TT，CC与TT+TC,C与T（OR=0.76，95％CI=0.65-0.89；OR=0.79，95％CI=0.68-0.92；OR=0.90，95％CI=0.85-0.95），分别;在分层分析后的亚组中观察到相似的结果.此外,在按种族进行分层分析后,该多态性也降低了亚洲人群的髋关节OA风险.
结论：BMP-14rs143383多态性可能是OA发生的保护因素。
