使用由单个共有登革热包膜序列组成的亚单位疫苗阐述针对登革热病毒的四价抗体应答。
关键词: Antibody dependent enhancement Antibody response Balanced immunogenicity Consensus envelope sequence T cell response Tetravalent dengue vaccine
Mesh : Animals Antibodies, Viral / blood Antibody Formation Baculoviridae / genetics Consensus Sequence / immunology Cross Protection Dengue Vaccines / administration & dosage genetics immunology Dengue Virus / genetics immunology Female Gene Expression Genetic Vectors Immunoglobulin G / blood Interferon-gamma / metabolism Interleukin-4 / metabolism Mice, Inbred BALB C Th1 Cells / immunology Th2 Cells / immunology Vaccines, Subunit / administration & dosage genetics immunology Vaccines, Synthetic / administration & dosage genetics immunology Viral Envelope Proteins / genetics immunology
来 源:
DOI:10.1016/j.vaccine.2017.09.063
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