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Abstract：
Because of the health effects of secondhand smoke, the Japanese government is trying to establish an effective law for total avoidance of secondhand smoke in indoor environments for tobacco-free Tokyo Olympic and Paralympic games 2020, as requested by the International Olympic Committee (IOC) and the World Health Organization (WHO). Meanwhile, Philip Morris International has begun selling a new heat-not-burn tobacco, iQOS, which it claims is designed not to produce secondhand smoke. There is little scientific data, however, of the hazards and toxicity of iQOS. In this study, we evaluated several harmful compounds (nicotine, tar, carbon monoxide (CO) and tobacco-specific nitrosamines (TSNAs)) in the mainstream smoke and fillers of iQOS, and compared their concentrations with those from conventional combustion cigarettes. The concentrations of nicotine in tobacco fillers and the mainstream smoke of iQOS were almost the same as those of conventional combustion cigarettes, while the concentration of TSNAs was one fifth and CO was one hundredth of those of conventional combustion cigarettes. These toxic compounds are not completely removed from the mainstream smoke of iQOS, making it necessary to consider the health effects and regulation of iQOS.
摘要：
由于二手烟对健康的影响，根据国际奥委会（IOC）和世界卫生组织（WHO）的要求，日本政府正在努力制定一项有效的法律，以在2020年东京奥运会和残奥会的无烟室内环境中完全避免二手烟。同时,菲利普莫里斯国际公司已经开始销售一种新的热不燃烧烟草，iQOS,它声称是为了不产生二手烟而设计的。科学数据很少,然而,iQOS的危害和毒性。在这项研究中,我们评估了几种有害化合物（尼古丁，tar,一氧化碳（CO）和烟草特有的亚硝胺（TSNA））在iQOS的主流烟雾和填料，并将它们的浓度与传统燃烧香烟的浓度进行了比较。烟叶填充剂和iQOS主流烟气中的尼古丁浓度与常规燃烧卷烟几乎相同,而TSNAs的浓度是传统燃烧卷烟的五分之一，CO的浓度是传统燃烧卷烟的百分之一。这些有毒化合物并没有完全从iQOS的主流烟雾中去除，这使得有必要考虑iQOS的健康影响和监管。
