关键词: calciphylaxis chronic lymphocytic leukemia nonuremic calciphylaxis pseudoxanthoma elasticum ulcers

Mesh : Aged, 80 and over Biopsy Blood Vessels / pathology Calciphylaxis / complications pathology Diagnosis, Differential Elastic Tissue / pathology Female Humans Kidney Failure, Chronic / complications Leg Ulcer / pathology Leukemia, Lymphocytic, Chronic, B-Cell / complications drug therapy pathology Middle Aged Pseudoxanthoma Elasticum / complications pathology

来  源:   DOI:10.1111/cup.13034   PDF(Sci-hub)

Abstract:
Calciphylaxis is a rare syndrome of vascular calcification with thrombosis that occurs most often in patients with end-stage renal disease, and it frequently portends a guarded prognosis. Rarely, nonuremic calciphylaxis (NUC) may occur; in this context, a strongly supportive histology is crucial in establishing the diagnosis. Herein, we describe 2 cases of NUC associated with pseudoxanthoma elasticum-like changes, identified in both initial nondiagnostic and subsequent diagnostic biopsy specimens. This unusual but helpful histologic finding may support the early diagnosis and treatment of a potentially life-threatening disease in the context of subtle histopathologic vascular changes or in the absence of classic clinical or laboratory findings.
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