The Procalcitonin Antibiotic Consensus Trial (ProACT) is a multicenter randomized trial to determine the impact of a procalcitonin antibiotic prescribing guideline, implemented with basic reproducible strategies, in US patients with lower respiratory tract infection.
We describe the trial methods using the Consolidated Standards of Reporting Trials (CONSORT) framework, and the rationale for key design decisions, including choice of eligibility criteria, choice of control arm, and approach to guideline implementation.
ClinicalTrials.gov NCT02130986 . Registered May 1, 2014.
降钙素原抗生素共识试验(ProACT)是一项多中心随机试验,旨在确定降钙素原抗生素处方指南的影响。用基本的可重复策略实施,美国下呼吸道感染患者。
我们使用合并报告试验标准(CONSORT)框架描述试验方法,以及关键设计决策的基本原理,包括资格标准的选择,控制臂的选择,以及指导方针实施的方法。
ClinicalTrials.govNCT02130986。2014年5月1日注册