Abstract：
Obesity is a late effect of antineoplastic treatment in childhood cancer survivors and this correlates with chronic complications. This review examines the data currently available to health professionals, for increasing awareness and identifying strategies to address the treatment and prevention of late effects. The mechanism involved in the pathophysiology of obesity remains unclear. However, damage to the hypothalamus and endocrine disorders (e.g. insulin and leptin resistance) and a positive energetic balance may play a role in increasing obesity rates. A patient\'s diet during, and after treatment may also influence the weight of survivors. Implementation of an effective educational program by professionals during all stages of treatment enables children to obtain basic knowledge regarding food and nutrition, thereby encouraging them to take responsibility for developing healthy eating behaviors.
摘要：
肥胖是儿童癌症幸存者抗肿瘤治疗的晚期效果，这与慢性并发症有关。这篇综述审查了卫生专业人员目前可获得的数据，提高认识和确定战略，以解决治疗和预防的后期影响。肥胖的病理生理学机制尚不清楚。然而,对下丘脑的损害和内分泌紊乱（例如胰岛素和瘦素抵抗）以及积极的能量平衡可能在增加肥胖率中起作用。一个病人的饮食期间，治疗后也可能影响幸存者的体重。专业人员在治疗的所有阶段实施有效的教育计划，使儿童能够获得有关食物和营养的基本知识，从而鼓励他们承担起发展健康饮食行为的责任。
