PDF(Pubmed)
Abstract：
Synthetic nerve conduits have emerged as an alternative to guide axonal regeneration in peripheral nerve gap injuries. Migration of Schwann cells (SC) from nerve stumps has been demonstrated as one essential factor for nerve regeneration in nerve defects. In this experiment, SC viability and migration were investigated for various materials to determine the optimal conditions for nerve regeneration. Cell viability and SC migration assays were conducted for collagen I, laminin, fibronectin, lysine and ornithine. The highest values for cell viability were detected for collagen I, whereas fibronectin was most stimulatory for SC migration. At this time, clinically approved conduits are based on single-material structures. In contrast, the results of this experiment suggest that material compounds such as collagen I in conjunction with fibronectin should be considered for optimal nerve healing.
摘要：
合成神经导管已成为周围神经间隙损伤中指导轴突再生的替代方法。已证明雪旺氏细胞（SC）从神经残端的迁移是神经缺损中神经再生的重要因素之一。在这个实验中,研究了各种材料的SC活力和迁移，以确定神经再生的最佳条件。对胶原蛋白I进行细胞活力和SC迁移测定，层粘连蛋白,纤连蛋白,赖氨酸和鸟氨酸.对于胶原蛋白I，检测到细胞活力的最高值。而纤连蛋白对SC迁移最具刺激性。此时,临床批准的导管基于单一材料结构。相比之下,该实验的结果表明，应考虑将胶原蛋白I和纤连蛋白结合使用的材料化合物用于最佳的神经愈合。
