Biliary bile acids in hepatobiliary injury - What is the link?

肝胆损伤中的胆汁酸 - 有什么联系 ？

• 影响指数: 30.083
• 发表时间: 09 2017
• 来源期刊: J Hepatol
• DOI: 10.1016/j.jhep.2017.04.026
• PMID: 28712691
• 文章类型: Journal Article
• 中科院分区: Q1
• 方向: 医学
• 作者列表: Fickert P,Wagner M

关键词: Bile canaliculus; Bile ducts; Bile secretion; Cholangiopathies; Cholangitis; Primary biliary cholangitis; Primary sclerosing cholangitis

Mesh: ATP Binding Cassette Transporter, Subfamily B / physiology; ATP Binding Cassette Transporter, Subfamily B, Member 11 / physiology; Animals; Apoptosis; Autophagy; Bile Acids and Salts / physiology; Carrier Proteins / physiology; Cholestasis / etiology; Humans; Liver / pathology; Liver Cirrhosis / etiology; Membrane Glycoproteins / physiology; Mice; ATP-Binding Cassette Sub-Family B Member 4

Abstract

The main trigger for liver injury in acquired cholestatic liver disease remains unclear. However, the accumulation of bile acids (BAs) undoubtedly plays a role. Recent progress in deciphering the pathomechanisms of inborn cholestatic liver diseases, decoding mechanisms of BA-induced cell death, and generating modern BA-derived drugs has improved the understanding of the regulation of BA synthesis and transport. Now is the appropriate time to reassess current knowledge about the specific role of BAs in hepatobiliary injury.

摘要

获得性胆汁淤积性肝病肝损伤的主要诱因仍不清楚。然而,胆汁酸（BA）的积累无疑起着一定的作用。先天性胆汁淤积性肝病发病机制的研究进展,BA诱导细胞死亡的解码机制，现代BA衍生药物的产生提高了对BA合成和运输调控的认识。现在是重新评估有关BA在肝胆损伤中的具体作用的最新知识的适当时机。