Cotransporting Ion 是转运蛋白靶向纳米颗粒细胞内吞作用的触发因素 : 高效 SLC22A5 ( OCTN2 ) 介导的肉碱共轭纳米颗粒口服给药的案例研究。
关键词: OCTN2 carnitine-conjugated nanoparticles cotransporting ions lymphatic absorption oral drug delivery
Mesh : Administration, Oral Biological Availability Caco-2 Cells Carnitine / chemical synthesis chemistry Endocytosis Humans Intestinal Absorption Ions Lactic Acid / chemistry Lymphatic System / drug effects Molecular Docking Simulation Nanoparticles / chemistry ultrastructure Paclitaxel / administration & dosage pharmacokinetics therapeutic use Photoelectron Spectroscopy Polyglycolic Acid / chemistry Polylactic Acid-Polyglycolic Acid Copolymer RNA, Messenger / genetics metabolism Sodium / chemistry Solute Carrier Family 22 Member 5 / genetics metabolism
来 源:
DOI:10.1002/adhm.201700165
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