Abstract：
This study aimed to investigate the cerebral function deficits in patients with leukoaraiosis (LA) and the correlation with white matter hyperintensity (WMH) using functional MRI (fMRI) technology.
Twenty-eight patients with LA and 30 volunteers were enrolled in this study. All patients underwent structural MRI and resting-state functional MRI (rs-fMRI) scanning. The amplitude of low-frequency fluctuations (ALFF) of rs-fMRI signals for the two groups was compared using two-sample t tests. A one-sample t test was performed on the individual z-value maps to identify the functional connectivity of each group. The z values were compared between the two groups using a two-sample t test. Partial correlations between ALFF values and functional connectivity of the brain regions that showed group differences and Fazekas scores of the WMH were analyzed.
Compared with the control group, the LA group showed a significant decrease in the ALFF in the left parahippocampal gyrus (PHG) and an increased ALFF in the left inferior semi-lunar lobule and right superior orbital frontal gyrus (SOFG). The patients with LA showed an increased functional connectivity between the right insular region and the right SOFG and between the right calcarine cortex and the left PHG. After the effects of age, gender, and years of education were corrected as covariates, the functional connectivity strength of the right insular and the right SOFG showed close correlations with the Fazekas scores.
Our results enhance the understanding of the pathomechanism of LA. Leukoaraiosis is associated with widespread cerebral function deficits, which show a close correlation with WMH and can be measured by rs-fMRI.
Twenty-eight patients with LA and 30 volunteers were enrolled in this study. All patients underwent structural MRI and resting-state functional MRI (rs-fMRI) scanning. The amplitude of low-frequency fluctuations (ALFF) of rs-fMRI signals for the two groups was compared using two-sample t tests. A one-sample t test was performed on the individual z-value maps to identify the functional connectivity of each group. The z values were compared between the two groups using a two-sample t test. Partial correlations between ALFF values and functional connectivity of the brain regions that showed group differences and Fazekas scores of the WMH were analyzed.
Compared with the control group, the LA group showed a significant decrease in the ALFF in the left parahippocampal gyrus (PHG) and an increased ALFF in the left inferior semi-lunar lobule and right superior orbital frontal gyrus (SOFG). The patients with LA showed an increased functional connectivity between the right insular region and the right SOFG and between the right calcarine cortex and the left PHG. After the effects of age, gender, and years of education were corrected as covariates, the functional connectivity strength of the right insular and the right SOFG showed close correlations with the Fazekas scores.
Our results enhance the understanding of the pathomechanism of LA. Leukoaraiosis is associated with widespread cerebral function deficits, which show a close correlation with WMH and can be measured by rs-fMRI.
摘要：
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