Cryptococcal Maxillary Osteomyelitis and Osteonecrosis in a 18-Month-Old Dog.

• 影响指数: 1.154
• 发表时间: 06 2017
• 来源期刊: J Vet Dent
• DOI: 10.1177/0898756417714025
• PMID: 28631547
• 文章类型: Case Reports
• 作者列表: Block K,Battig J

关键词: Cryptococcus; Cryptococcus gattii; bone sequestra; cryptococcosis; fungal inoculation; fungal osteomyelitis; maxillary osteomyelitis; veterinary dentistry

Mesh: Animals; Antifungal Agents / administration & dosage; Cryptococcosis / diagnosis drug therapy surgery veterinary; Cryptococcus / physiology; Debridement / veterinary; Dog Diseases / diagnosis drug therapy surgery; Dogs; Fluconazole / administration & dosage; Male; Maxillary Diseases / diagnosis drug therapy surgery veterinary; Osteomyelitis / diagnosis drug therapy surgery veterinary; Osteonecrosis / diagnosis drug therapy surgery veterinary

Abstract

An 18-month-old neutered male labradoodle was treated with surgical debridement for maxillary osteomyelitis and sequestrum formation. Histopathologic findings of the necrotic bone were consistent with Cryptococcus subspecies, confirmed with latex agglutination serum titer testing. The patient responded to a combination of fluconazole and surgical debridement and was titer negative after 8 months of medical therapy. The patient never exhibited signs of systemic illness which is commonly reported with cryptococcosis. Cryptococcus subspecies infection in dogs in the Pacific Northwest is part of an ongoing outbreak in the region, first reported in 2001, and is associated with specific risk factors. This is the first published case of oral cryptococcosis from primary inoculation.