关键词: Crohn's disease Inflammatory Bowel Disease fecal microbiota transplant ulcerative colitis

Mesh : Animals Clostridium Infections / therapy Disease Models, Animal Fecal Microbiota Transplantation Feces / microbiology Gastrointestinal Microbiome Helminthiasis / therapy Humans Inflammatory Bowel Diseases / therapy Intestines / microbiology Randomized Controlled Trials as Topic Treatment Outcome

来  源:   DOI:10.1080/19490976.2017.1290757   PDF(Sci-hub)

Abstract:
Inflammatory bowel disease (IBD) is a complex set of diseases that lead to chronic inflammation in the gastrointestinal tract. Although the etiology of IBD is not fully understood, it is well-known that the intestinal microbiota is associated with the development and maintenance of IBD. Manipulation of the gut microbiota, therefore, may represent a target for IBD therapy. Fecal microbiota transplantation (FMT), where fecal microbiota from a healthy donor is transplanted into a patient\'s GI tract, is already a successful therapy for Clostridium difficile infection. FMT is currently being explored as a potential therapy for IBD as well. In this review, the associations between the gut microbiota and IBD and the emerging data on FMT for IBD will be discussed.
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