关键词: Evolution LncRNA MicroRNA Non-coding RNA Primate-specific

Mesh : Alu Elements / genetics Alzheimer Disease / genetics pathology veterinary Animals Depressive Disorder, Major / genetics pathology Evolution, Molecular Gene Expression Regulation MicroRNAs / genetics metabolism Primates RNA, Long Noncoding / genetics metabolism X Chromosome / genetics

来  源:   DOI:10.1016/j.gpb.2017.04.002   PDF(Sci-hub)

Abstract:
Non-coding RNAs (ncRNAs) are critical regulators of gene expression in essentially all life forms. Long ncRNAs (lncRNAs) and microRNAs (miRNAs) are two important RNA classes possessing regulatory functions. Up to date, many primate-specific ncRNAs have been identified and investigated. Their expression specificity to primate lineage suggests primate-specific roles. It is thus critical to elucidate the biological significance of primate or even human-specific ncRNAs, and to develop potential ncRNA-based therapeutics. Here, we have summarized the studies regarding regulatory roles of some key primate-specific lncRNAs and miRNAs.
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