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Abstract：
To assess the prevalence, clinical features and risk factors of lower lid epiblepharon among patients with congenital glaucoma.
Cross-sectional, observational, case-control study. Patients diagnosed with congenital glaucoma between August 1999 and November 2014 were included. Demographic and clinical characteristic data were collected. Age-matched normal controls were recruited form general population. Main outcome measures were the prevalence, laterality and factors associated with epiblepharon in patients with congenital glaucoma.
The prevalence of lower lid epiblepharon was higher in patients with congenital glaucoma compared with control group (40.7% vs 13.3%, p<0.001). Unilateral epiblepharon was only shown in patients with congenital glaucoma (47.8% vs 0.0%, p<0.001). Multivariate analysis revealed that high intraocular pressure (IOP) at glaucoma diagnosis (OR=1.122), presence of corneal erosion (OR=82.664) and presence of buphthalmos (OR=12.600) were significantly associated with the presence of lower lid epiblepharon. In addition, unilateral epiblepharon was associated with unilateral buphthalmos and unilateral glaucoma (OR of 49.849 and 7.338, respectively).
The prevalence of epiblepharon was higher in patients with congenital glaucoma compared with age-matched general population. In patients with congenital glaucoma, epiblepharon was associated with corneal erosions. In addition, buphthalmos and initial high IOP were associated with the development of lower lid epiblepharon. More importantly, unilateral buphthalmos was also significantly associated with unilateral epiblepharon. Therefore, in patients with congenital glaucoma, presence of epiblepharon should be evaluated especially in patients accompanying buphthalmos or corneal erosion.
Cross-sectional, observational, case-control study. Patients diagnosed with congenital glaucoma between August 1999 and November 2014 were included. Demographic and clinical characteristic data were collected. Age-matched normal controls were recruited form general population. Main outcome measures were the prevalence, laterality and factors associated with epiblepharon in patients with congenital glaucoma.
The prevalence of lower lid epiblepharon was higher in patients with congenital glaucoma compared with control group (40.7% vs 13.3%, p<0.001). Unilateral epiblepharon was only shown in patients with congenital glaucoma (47.8% vs 0.0%, p<0.001). Multivariate analysis revealed that high intraocular pressure (IOP) at glaucoma diagnosis (OR=1.122), presence of corneal erosion (OR=82.664) and presence of buphthalmos (OR=12.600) were significantly associated with the presence of lower lid epiblepharon. In addition, unilateral epiblepharon was associated with unilateral buphthalmos and unilateral glaucoma (OR of 49.849 and 7.338, respectively).
The prevalence of epiblepharon was higher in patients with congenital glaucoma compared with age-matched general population. In patients with congenital glaucoma, epiblepharon was associated with corneal erosions. In addition, buphthalmos and initial high IOP were associated with the development of lower lid epiblepharon. More importantly, unilateral buphthalmos was also significantly associated with unilateral epiblepharon. Therefore, in patients with congenital glaucoma, presence of epiblepharon should be evaluated especially in patients accompanying buphthalmos or corneal erosion.
摘要：
为了评估患病率，目的探讨先天性青光眼患者下眼睑眼睑的临床特征及危险因素.
横截面，观察,病例对照研究。纳入1999年8月至2014年11月诊断为先天性青光眼的患者。收集人口统计学和临床特征数据。从普通人群中招募年龄匹配的正常对照。主要结果指标是患病率，先天性青光眼患者眼睑的侧向性和相关因素。
与对照组相比，先天性青光眼患者下眼睑眼睑的患病率较高（40.7%vs13.3%，p<0.001)。仅在先天性青光眼患者中显示单侧上睑（47.8％vs0.0％，p<0.001)。多因素分析显示高眼压(IOP)在青光眼诊断中(OR=1.122),角膜糜烂的存在(OR=82.664)和buthelmos的存在(OR=12.600)与下眼睑眼睑的存在显著相关.此外,单侧上睑与单侧白眼和单侧青光眼相关(OR分别为49.849和7.338).
与年龄匹配的普通人群相比，先天性青光眼患者的上睑患病率较高。在先天性青光眼患者中，上睑与角膜糜烂有关。此外,白眼和最初的高眼压与下眼睑眼睑的发展有关。更重要的是,单侧白眼也与单侧上睑显著相关.因此,先天性青光眼患者，尤其是在伴有Buthelmos或角膜糜烂的患者中，应评估上睑的存在。
横截面，观察,病例对照研究。纳入1999年8月至2014年11月诊断为先天性青光眼的患者。收集人口统计学和临床特征数据。从普通人群中招募年龄匹配的正常对照。主要结果指标是患病率，先天性青光眼患者眼睑的侧向性和相关因素。
与对照组相比，先天性青光眼患者下眼睑眼睑的患病率较高（40.7%vs13.3%，p<0.001)。仅在先天性青光眼患者中显示单侧上睑（47.8％vs0.0％，p<0.001)。多因素分析显示高眼压(IOP)在青光眼诊断中(OR=1.122),角膜糜烂的存在(OR=82.664)和buthelmos的存在(OR=12.600)与下眼睑眼睑的存在显著相关.此外,单侧上睑与单侧白眼和单侧青光眼相关(OR分别为49.849和7.338).
与年龄匹配的普通人群相比，先天性青光眼患者的上睑患病率较高。在先天性青光眼患者中，上睑与角膜糜烂有关。此外,白眼和最初的高眼压与下眼睑眼睑的发展有关。更重要的是,单侧白眼也与单侧上睑显著相关.因此,先天性青光眼患者，尤其是在伴有Buthelmos或角膜糜烂的患者中，应评估上睑的存在。
