PDF(Pubmed)
Abstract：
Nanomedicine has seen a significant increase in research on stimuli-responsive activatable nanoprobes for tumor-specific delivery and diagnosis. The tumor microenvironment has particular characteristics that can be exploited to implement therapeutic strategies based on disparities between normal tissues and tumor tissues, including differences in pH, oxygenation, enzymatic expression, gene activation/inactivation, and vasculature. The nanocarriers of activatable nanoparticles maintain their structure while circulating in the body and, upon reaching the tumor site, are altered by unique tumoral stimuli, leading to the release of a drug or other agent. This review demonstrates the latest achievements in the use of internal stimuli-responsive, activatable nanoparticles with respect to unique design strategies and applications.
摘要：
纳米医学在用于肿瘤特异性递送和诊断的刺激响应性可激活纳米探针的研究中已经看到显著增加。肿瘤微环境具有特定的特征，可以利用这些特征来实施基于正常组织和肿瘤组织之间差异的治疗策略。包括pH值的差异，氧合，酶促表达，基因激活/失活，和脉管系统。可活化纳米粒子的纳米载体在体内循环时保持其结构,到达肿瘤部位后，被独特的肿瘤刺激改变，导致药物或其他药剂的释放。这篇综述展示了在使用内部刺激响应，可活化的纳米颗粒具有独特的设计策略和应用。
