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Abstract：
The Notch pathway represents a conserved signal transduction machinery that is straightforward and based on a few elements (ligands, receptors, transducers). However, the existence of multiple control levels of the Notch signaling final outcome makes it strictly context dependent and dose dependent. The function of Notch as a regulator of cell development and differentiation, as well as the aberrant consequences of its modulation, either positive or negative, is well established. In this review, we will discuss our current knowledge about Notch-dependent regulation of generation and function of 2 subsets of the immunoregulatory system, namely regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs). Then, we will focus on an unforeseen mechanism that may unveil an additional way of Notch to govern the surrounding environment in cancer.
摘要：
Notch通路代表了一种保守的信号转导机制，它是简单的，基于几个元素(配体，受体,传感器)。然而,Notch信号传导最终结果的多个对照水平的存在使其严格依赖于上下文和剂量依赖性。Notch作为细胞发育和分化调节因子的功能,以及其调制的异常后果，无论是积极的还是消极的，建立得很好。在这次审查中,我们将讨论我们目前有关Notch依赖性调节免疫调节系统2个子集的生成和功能的知识，即调节性T细胞(Tregs)和髓源性抑制细胞(MDSC)。然后，我们将专注于一种不可预见的机制，该机制可能揭示一种额外的Notch方式来管理癌症的周围环境。
