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Abstract：
BACKGROUND: This study examined the operating characteristics of two-stage case finding to identify memory impairment and very mild dementia.
METHODS: Primary care patients underwent two-stage testing and a subsequent diagnostic assessment to assess outcomes. Patients who screen positive for subjective cognitive decline on the Informant Questionnaire on Cognitive Decline in the Elderly undergo memory testing with the Free and Cued Selective Reminding Test with Immediate Recall. Outcomes were determined without access to these data. A split-half design with discovery and confirmatory samples was used.
RESULTS: One hundred seventeen of 563 (21%) patients had dementia and 68 (12%) had memory impairment but not dementia. Operating characteristics were similar in the discovery and confirmatory samples. In the pooled sample, combined, patients with memory impairment or dementia were identified with good sensitivity (72%) and high specificity (90%). Differences in ethnicity, educational level, or age (≤75, >75) did not affect classification accuracy.
CONCLUSIONS: Two-stage screening facilitates the efficient identification of older adults with memory impairment or dementia.
METHODS: Primary care patients underwent two-stage testing and a subsequent diagnostic assessment to assess outcomes. Patients who screen positive for subjective cognitive decline on the Informant Questionnaire on Cognitive Decline in the Elderly undergo memory testing with the Free and Cued Selective Reminding Test with Immediate Recall. Outcomes were determined without access to these data. A split-half design with discovery and confirmatory samples was used.
RESULTS: One hundred seventeen of 563 (21%) patients had dementia and 68 (12%) had memory impairment but not dementia. Operating characteristics were similar in the discovery and confirmatory samples. In the pooled sample, combined, patients with memory impairment or dementia were identified with good sensitivity (72%) and high specificity (90%). Differences in ethnicity, educational level, or age (≤75, >75) did not affect classification accuracy.
CONCLUSIONS: Two-stage screening facilitates the efficient identification of older adults with memory impairment or dementia.
摘要：
背景：这项研究检查了两阶段病例的操作特征，以确定记忆障碍和极轻度痴呆。
方法：初级保健患者接受两阶段测试和随后的诊断评估以评估结果。在老年人认知衰退的告密者问卷上筛查主观认知衰退呈阳性的患者，将接受免费和提示选择性提醒测试并立即召回的记忆测试。结果是在没有获得这些数据的情况下确定的。使用了具有发现和确认样本的半分割设计。
结果：563名患者中有117名（21％）患有痴呆，68名（12％）患有记忆障碍，但没有痴呆。在发现和确认样品中的操作特征相似。在合并的样本中，合并,记忆障碍或痴呆患者的诊断敏感性良好(72%),特异性高(90%).种族差异,教育水平,或年龄(≤75,>75)不影响分类准确性。
结论：两阶段筛查有助于有效识别患有记忆障碍或痴呆的老年人。
方法：初级保健患者接受两阶段测试和随后的诊断评估以评估结果。在老年人认知衰退的告密者问卷上筛查主观认知衰退呈阳性的患者，将接受免费和提示选择性提醒测试并立即召回的记忆测试。结果是在没有获得这些数据的情况下确定的。使用了具有发现和确认样本的半分割设计。
结果：563名患者中有117名（21％）患有痴呆，68名（12％）患有记忆障碍，但没有痴呆。在发现和确认样品中的操作特征相似。在合并的样本中，合并,记忆障碍或痴呆患者的诊断敏感性良好(72%),特异性高(90%).种族差异,教育水平,或年龄(≤75,>75)不影响分类准确性。
结论：两阶段筛查有助于有效识别患有记忆障碍或痴呆的老年人。
