关键词: Candida albicans acute liver failure fungemia human herpesvirus 1

Mesh : Antifungal Agents / therapeutic use Antiviral Agents / therapeutic use Candida albicans / growth & development isolation & purification Candidiasis / diagnosis microbiology therapy Cardiac Surgical Procedures Echocardiography, Transesophageal Herpes Simplex / diagnosis drug therapy virology Herpesvirus 1, Human / isolation & purification Humans Infant, Newborn Infant, Newborn, Diseases / diagnosis microbiology therapy virology Intensive Care Units, Neonatal Liver Failure / diagnosis drug therapy virology Male Superinfection Treatment Outcome Ventricular Outflow Obstruction / diagnostic imaging microbiology therapy

来  源:   DOI:10.14797/mdcj-12-4-225

Abstract:
Systemic fungal infections pose insidious challenges in neonatal intensive care settings. We present the case of a 9-day-old male term neonate admitted for polymicrobial sepsis and hepatic dysfunction who later developed candidemia superinfection. Despite broad antifungal therapy, the fungemia was complicated by progressive growth of a fungus ball in the right ventricular outflow tract that threatened cardiac function. Surgical excision of the mass was undertaken by right atriotomy and histologic examination confirmed Candida albicans.
摘要:
系统性真菌感染在新生儿重症监护环境中提出了潜在的挑战。我们介绍了一名9天大的男性足月新生儿因多微生物败血症和肝功能障碍而入院的情况,后来发生了念珠菌菌血症重复感染。尽管有广泛的抗真菌治疗,右心室流出道中真菌球的进行性生长使真菌血症变得复杂,从而威胁到心脏功能。通过右心房切开术和组织学检查证实的白色念珠菌对肿块进行手术切除。
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