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Abstract：
Edible seaweeds have been consumed by Asian coastal communities since ancient times. Fucus vesiculosus and Ascophyllum nodosum extracts have been traditionally used for the treatment of obesity and several gastrointestinal diseases. We evaluated the ability of extracts obtained from these algae to inhibit the digestive enzymes α-amylase and α-glucosidase in vitro, and control postprandial plasma glucose levels in a mouse model of non-alcoholic steatohepatitis (NASH); a liver disease often preceding the development of Type 2 diabetes (T2DM). This model was obtained by the administration of a high-fat diet. Our results demonstrate that these algae only delayed and reduced the peak of blood glucose (p < 0.05) in mice fed with normal diet, without changing the area under the blood glucose curve (AUC). In the model of NASH, the phytocomplex was able to reduce both the postprandial glycaemic peak, and the AUC. The administration of the extract in a diet particularly rich in fat is associated with a delay in carbohydrate digestion, but also with a decrease in its assimilation. In conclusion, our results indicate that this algal extract may be useful in the control of carbohydrate digestion and absorption. This effect may be therapeutically exploited to prevent the transition of NASH to T2DM.
摘要：
自古以来，亚洲沿海社区就食用食用海藻。岩藻和夜蛾提取物传统上用于治疗肥胖症和几种胃肠道疾病。我们评估了从这些藻类中获得的提取物在体外抑制消化酶α-淀粉酶和α-葡萄糖苷酶的能力，在非酒精性脂肪性肝炎（NASH）的小鼠模型中控制餐后血浆葡萄糖水平；通常在2型糖尿病（T2DM）发展之前的肝病。该模型是通过给予高脂肪饮食获得的。我们的结果表明，这些藻类仅延迟和降低正常饮食喂养的小鼠的血糖峰值（p<0.05），而不改变血糖曲线下面积（AUC）。在NASH的模型中，植物复合物能够降低餐后血糖峰值，和AUC。在特别富含脂肪的饮食中施用提取物与碳水化合物消化的延迟有关，但也随着其同化的减少。总之,我们的结果表明，这种藻类提取物可能有助于控制碳水化合物的消化和吸收。这种作用可以在治疗上用于预防NASH向T2DM的转变。
