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Abstract：
With the major development of immunotherapies, evaluation of the immune response associated to cancer has become the new challenge for pathologists. In breast cancer, this perspective has been notably anticipated by the recent publication, in 2014, of international guidelines for assessment of tumor-infiltrating lymphocytes (TILs), on routine haematoxylin-eosin stains. This technical article aims at reviewing the main key points and different steps in evaluation of tumor-infiltrating lymphocytes, in order to allow an easy implementation of this putative biomarker in routine practice. Widespread diffusion of international guidelines is the key to development of a standardized and reproducible biomarker. This early learning phase is of particular importance, as immune response will probably play a major role as a prognostic and predictive biomarker, especially in triple-negative and HER2 positive breast cancer.
摘要：
随着免疫疗法的重大发展，评估与癌症相关的免疫反应已成为病理学家的新挑战。在乳腺癌中，最近的出版物特别预期了这一观点，2014年，国际肿瘤浸润淋巴细胞评估指南(TIL)，常规苏木精-伊红染色。本文旨在综述肿瘤浸润淋巴细胞评价的主要要点和不同步骤,以便在常规实践中轻松实施该推定的生物标志物。国际指南的广泛传播是开发标准化和可重复的生物标志物的关键。这个早期学习阶段特别重要，因为免疫反应可能会作为预后和预测生物标志物发挥重要作用，尤其是三阴性和HER2阳性乳腺癌。
