PDF(Pubmed)
Abstract：
Due to increasing shortage of public healthcare resources in many countries around the globe, the use of simple, rapid and inexpensive laboratory parameters may be seen as a valuable aid for preliminary and cost-effective risk stratification of patients. Anisocytosis, conventionally measured by hematologic analyzers as the red blood cell distribution width (RDW), is an index of the heterogeneity of erythrocytes volumes. Several lines of evidence now attest that increased RDW values are commonplace in patients with many disorders, especially in those with the most prevalent conditions such as cardiovascular disease, diabetes, cancer and infections. Although the nature of this association remains to be definitely disclosed, what is strongly emerging from the recent scientific research is that the RDW should now be regarded as a \"non\" innocent bystander, wherein anisocytosis may be an active player in the pathogenesis of many pathologies. Therefore, major attention should be placed on this inexpensive but clinically meaningful parameter. The recent finding that dynamic changes of RDW are strongly predictors of mortality also suggests that continuous monitoring of anisocytosis may be an ancillary useful tool for establishing the effectiveness of managed care, as well as for deciding whether or not the overall clinical status is improving.
摘要：
由于全球许多国家的公共医疗资源日益短缺，使用简单，快速且廉价的实验室参数可能被视为对患者进行初步且具有成本效益的风险分层的有价值的辅助手段.异细胞增多症,常规由血液分析仪测量为红细胞分布宽度(RDW)，是红细胞体积异质性的指标。现在有几条证据证明，在许多疾病的患者中，RDW值增加是司空见惯的。尤其是那些最普遍的疾病，如心血管疾病，糖尿病,癌症和感染。尽管这种协会的性质仍有待明确披露，从最近的科学研究中强烈出现的是，RDW现在应该被视为一个“非”无辜的旁观者，其中异细胞增多症可能是许多病理的发病机理中的活跃参与者。因此,应将主要注意力放在这个廉价但有临床意义的参数上.最近发现RDW的动态变化是死亡率的强烈预测因子，这也表明持续监测无异细胞增多可能是建立管理式护理有效性的辅助有用工具。以及确定整体临床状况是否正在改善。
