关键词: Crohn disease Enfermedad de Crohn Enfermedad inflamatoria intestinal Etiopatogenia Hidradenitis suppurativa Hidradenitis supurativa Inflammatory bowel disease Pathogenesis

Mesh : Adaptive Immunity Autophagy / genetics Bacterial Translocation / genetics Causality Comorbidity Crohn Disease / epidemiology etiology genetics immunology Cytokines / metabolism Environmental Exposure Genes, Dominant Genetic Predisposition to Disease Hidradenitis Suppurativa / epidemiology etiology genetics immunology Humans Immunity, Innate Lymphocyte Activation / genetics Microbiota Obesity / epidemiology Smoking / adverse effects Stress, Psychological / complications immunology Toll-Like Receptors / immunology

来  源:   DOI:10.1016/S0001-7310(17)30004-2

Abstract:
Both hidradenitis suppurativa and Crohn disease are considered chronic inflammatory diseases due to immune dysregulation. The high prevalence of Crohn disease patients diagnosed with hidradenitis suppurativa suggests the existence of common pathogenic links. The present literature review analyses the similarities and differences in the pathogenesis of the two diseases, in the search for new research and knowledge targets.
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