S1P3 受体亚型与 S1P 介导的 RhoA 激活和心脏保护的选择性偶联。
关键词: Cardioprotection G protein-coupled receptor (GPCR) Ischemia/reperfusion (I/R) Phospholipase C (PLC) Protein kinase D (PKD) Ras homolog gene family member A (RhoA) Sphingosine-1-phosphate (S1P)
Mesh : Animals Cardiomegaly / etiology metabolism pathology Lysophospholipids / metabolism Male Mice Myocardial Reperfusion Injury / metabolism Myocardium / metabolism Myocytes, Cardiac / metabolism Proprotein Convertases / metabolism Protein Binding Rats Receptors, Lysosphingolipid / metabolism Serine Endopeptidases / metabolism Signal Transduction Sphingosine / analogs & derivatives metabolism TRPP Cation Channels / metabolism rhoA GTP-Binding Protein / metabolism
来 源:
DOI:10.1016/j.yjmcc.2016.12.008
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