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Abstract：
BACKGROUND: The prognostic role of 18F-fluorodeoxyglucose positron emission tomography CT (18F-FDG PET/CT) parameters is still controversial in nasopharyngeal carcinoma patients. We sought to perform a systematic review and meta-analysis to explore the prognostic value of maximal standardized uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) on event-free survival (EFS) and overall survival (OS) in nasopharyngeal carcinoma patients.
RESULTS: Fifteen studies comprising 1,938 patients were included in this study. The combined hazard ratios (HRs) for EFS were 2.63 (95%CI 1.71-4.05) for SUVmax, 2.55 (95%CI 1.49-4.35) for MTV, and 3.32 (95%CI 1.23-8.95) for TLG. The pooled HRs for OS were 2.07 (95%CI 1.54-2.79) for SUVmax, 3.86 (95%CI 1.85-8.06) for MTV, and 2.60 (95%CI 1.55-4.34) for TLG. The prognostic role of SUVmax, MTV and TLG remained similar in the sub-group analyses.
METHODS: A systematic literature search was performed to identify studies which associated 18F-FDG PET/CT to clinical survival outcomes of nasopharyngeal carcinoma patients. The summarized HRs for EFS and OS were estimated by using fixed- or random-effect models according to heterogeneity between trials.
CONCLUSIONS: The present meta-analysis confirms that high values of SUVmax, MTV and TLG predicted a higher risk of adverse events or death in patients with nasopharyngeal carcinoma, despite clinically heterogeneous nasopharyngeal carcinoma patients and the various methods adopted between these studies.
RESULTS: Fifteen studies comprising 1,938 patients were included in this study. The combined hazard ratios (HRs) for EFS were 2.63 (95%CI 1.71-4.05) for SUVmax, 2.55 (95%CI 1.49-4.35) for MTV, and 3.32 (95%CI 1.23-8.95) for TLG. The pooled HRs for OS were 2.07 (95%CI 1.54-2.79) for SUVmax, 3.86 (95%CI 1.85-8.06) for MTV, and 2.60 (95%CI 1.55-4.34) for TLG. The prognostic role of SUVmax, MTV and TLG remained similar in the sub-group analyses.
METHODS: A systematic literature search was performed to identify studies which associated 18F-FDG PET/CT to clinical survival outcomes of nasopharyngeal carcinoma patients. The summarized HRs for EFS and OS were estimated by using fixed- or random-effect models according to heterogeneity between trials.
CONCLUSIONS: The present meta-analysis confirms that high values of SUVmax, MTV and TLG predicted a higher risk of adverse events or death in patients with nasopharyngeal carcinoma, despite clinically heterogeneous nasopharyngeal carcinoma patients and the various methods adopted between these studies.
摘要：
背景：18F-氟代脱氧葡萄糖正电子发射断层扫描CT（18F-FDGPET/CT）参数在鼻咽癌患者中的预后作用仍存在争议。我们试图进行系统评价和荟萃分析，以探讨最大标准化摄取值（SUVmax）的预后价值，代谢肿瘤体积（MTV）和总病变糖酵解（TLG）对鼻咽癌患者无事件生存期（EFS）和总生存期（OS）的影响。
结果：本研究包括15项研究，包括1,938名患者。对于SUVmax，EFS的综合风险比（HR）为2.63（95CI1.71-4.05），MTV为2.55（95CI1.49-4.35），TLG为3.32（95CI1.23-8.95）。对于SUVmax，OS的合并HR为2.07（95CI1.54-2.79），用于MTV的3.86（95CI1.85-8.06），TLG为2.60（95CI1.55-4.34）。SUVmax的预后作用，MTV和TLG在亚组分析中保持相似。
方法：进行了系统的文献检索，以确定18F-FDGPET/CT与鼻咽癌患者临床生存结局相关的研究。根据试验之间的异质性，通过使用固定或随机效应模型来估计EFS和OS的汇总HR。
结论：本荟萃分析证实，SUVmax的高值，MTV和TLG预测鼻咽癌患者发生不良事件或死亡的风险较高。尽管鼻咽癌患者的临床异质性以及这些研究之间采用的各种方法。
结果：本研究包括15项研究，包括1,938名患者。对于SUVmax，EFS的综合风险比（HR）为2.63（95CI1.71-4.05），MTV为2.55（95CI1.49-4.35），TLG为3.32（95CI1.23-8.95）。对于SUVmax，OS的合并HR为2.07（95CI1.54-2.79），用于MTV的3.86（95CI1.85-8.06），TLG为2.60（95CI1.55-4.34）。SUVmax的预后作用，MTV和TLG在亚组分析中保持相似。
方法：进行了系统的文献检索，以确定18F-FDGPET/CT与鼻咽癌患者临床生存结局相关的研究。根据试验之间的异质性，通过使用固定或随机效应模型来估计EFS和OS的汇总HR。
结论：本荟萃分析证实，SUVmax的高值，MTV和TLG预测鼻咽癌患者发生不良事件或死亡的风险较高。尽管鼻咽癌患者的临床异质性以及这些研究之间采用的各种方法。
