RESULTS: Fifteen studies comprising 1,938 patients were included in this study. The combined hazard ratios (HRs) for EFS were 2.63 (95%CI 1.71-4.05) for SUVmax, 2.55 (95%CI 1.49-4.35) for MTV, and 3.32 (95%CI 1.23-8.95) for TLG. The pooled HRs for OS were 2.07 (95%CI 1.54-2.79) for SUVmax, 3.86 (95%CI 1.85-8.06) for MTV, and 2.60 (95%CI 1.55-4.34) for TLG. The prognostic role of SUVmax, MTV and TLG remained similar in the sub-group analyses.
METHODS: A systematic literature search was performed to identify studies which associated 18F-FDG PET/CT to clinical survival outcomes of nasopharyngeal carcinoma patients. The summarized HRs for EFS and OS were estimated by using fixed- or random-effect models according to heterogeneity between trials.
CONCLUSIONS: The present meta-analysis confirms that high values of SUVmax, MTV and TLG predicted a higher risk of adverse events or death in patients with nasopharyngeal carcinoma, despite clinically heterogeneous nasopharyngeal carcinoma patients and the various methods adopted between these studies.
结果:本研究包括15项研究,包括1,938名患者。对于SUVmax,EFS的综合风险比(HR)为2.63(95CI1.71-4.05),MTV为2.55(95CI1.49-4.35),TLG为3.32(95CI1.23-8.95)。对于SUVmax,OS的合并HR为2.07(95CI1.54-2.79),用于MTV的3.86(95CI1.85-8.06),TLG为2.60(95CI1.55-4.34)。SUVmax的预后作用,MTV和TLG在亚组分析中保持相似。
方法:进行了系统的文献检索,以确定18F-FDGPET/CT与鼻咽癌患者临床生存结局相关的研究。根据试验之间的异质性,通过使用固定或随机效应模型来估计EFS和OS的汇总HR。
结论:本荟萃分析证实,SUVmax的高值,MTV和TLG预测鼻咽癌患者发生不良事件或死亡的风险较高。尽管鼻咽癌患者的临床异质性以及这些研究之间采用的各种方法。